Researcher
Dirk Snyders
- Research Expertise:Electrophysiological analysis and Patch clamp.
- Keywords:STABLE CELL LINE GENERATION, PATCH-CLAMP, CHANNEL GATING, MOLECULAR CELL BIOLOGY OF ION CHANNELS, Biomedical sciences (incl. biochemistry)
- Disciplines:Medicinal and biomolecular chemistry, Molecular and cell biology, Plant biology, Systems biology, Biophysics, Cardiac and vascular medicine, Neurosciences, Physiology, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
- Research techniques:- Electrophysiological analysis - Patch clamp
- Users of research expertise:Pharmaceutical industry.
Affiliations
- Experimental Neurobiology Unit (ENU) (Research group)
Member
From1 Oct 2021 → Today - Molecular, Cellular and Network Excitability (MCNE) (Research group)
Responsible
From1 Jan 2020 → 30 Sep 2021 - Molecular, Cellular and Network Excitability (MCNE) (Research group)
Member
From1 Jan 2018 → 31 Dec 2019 - Molecular biophysics, physiology and pharmacology (Research group)
Responsible
From1 Oct 2003 → 31 Dec 2017
Projects
1 - 10 of 22
- Elucidating the pathogenicity of genetic variants of uncertain significance in Brugada syndrome patients by functional modelling in hiPSC-derived cardiomyocytes and zebrafish.From1 Nov 2020 → TodayFunding: FWO fellowships
- Multi-well microelectrode array (MEA): a bridge to highthroughput electrophysiology.From1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- A zebrafish model system to assess pathogenicity of genetic variants in patients with cardiac arrhythmias.From1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Molecular elucidation of the unique gating behavior of cardiac ion channels thanks to their interaction with conopeptides.From1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- New and safer tools to cure cardiac arrhythmias through genetic-manipulation-free photothermal stimulation and enhanced photothermal ablation of cardiomyocytes.From1 Jan 2019 → 31 Oct 2019Funding: BOF - doctoral mandates
- Development of a functional assay to determine the pathogenicity of genetic variants with unknown significance identified in patients with cardiac arrhythmia.From1 Oct 2018 → 30 Sep 2022Funding: FWO fellowships
- Inherited cardiac arrhythmias: identification of novel genes and development of a new diagnostic tool for translating genetic diagnosis into precision medicine.From1 Jan 2017 → 31 Dec 2020Funding: BOF - Concerted Research Project from 1994
- The pharmacological profile of homomtetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels depends on the channel's inactivation gating.From1 Oct 2015 → 30 Jan 2017Funding: FWO fellowships
- "Silent" voltage-gated K+ channel subunits – no simple silent bystanders: analysis of their pharmacological profile, physiological role and gating mechanism.From1 Oct 2015 → 31 May 2016Funding: FWO fellowships
- Molecular architecture and assembly of heteromeric membrane proteins.From1 Jan 2015 → 31 Dec 2017Funding: Fund Recuperation Fiscal Exemption
Publications
31 - 40 of 54
- The subfamily-specific interaction between Kv2.1 and Kv6.4 subunits is determined by interactions between the N- and C-termini(2014)
Authors: Elke Bocksteins, Evy Mayeur, Abbi Van Tilborg, Glenn Regnier, Jean-Pierre Timmermans, Dirk Snyders
- The interactions of apamin and tetraethylammonium are differentially affected by single mutations in the pore mouth of small conductance calcium-activated potassium (SK) channels(2013)
Authors: Sébastien Dilly, Fabian Philippart, Cédric Lamy, Sylvie Poncin, Dirk Snyders, Vincent Seutin, Jean-François Liégeois
Pages: 560 - 569 - The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state(2013)
Authors: Ivan Kopljar, Alain Labro, Tessa de Block, Jon D. Rainier, Jan Tytgat, Dirk Snyders
Pages: 359 - 369 - Kv3.3b expression defines the shape of the complex spike in the Purkinje cell(2013)
Authors: Ken Veys, Dirk Snyders, Erik De Schutter
Pages: 1 - 10 - The electrically silent Kv6.4 subunit confers hyperpolarized gating charge movement in Kv2.1/Kv6.4 heterotetrameric channels(2012)
Authors: Elke Bocksteins, Alain Labro, Dirk Snyders, Durga P. Mohapatra
- Immunostaining of voltage-gated ion channels in cell lines and neurons(2012)
Authors: Elke Bocksteins, A. Shepherd, D.P. Mohapatra, Dirk Snyders
Pages: 3 - 28 - Being flexible(2012)
Authors: Alain Labro, Dirk Snyders
- $K{v}3$ channels contribute to the delayed rectifier current in small cultured mouse dorsal root ganglion neurons(2012)
Authors: Elke Bocksteins, Gerda Van de Vijver, Pierre-Paul Van Bogaert, Dirk Snyders
Pages: C406 - C415 - Electrically silent Kv subunits(2012)
Authors: Elke Bocksteins, Dirk Snyders
Pages: 73 - 84 - Molecular mechanism for depolarization-induced modulation of Kv channel closure(2012)
Authors: Alain Labro, Jerome J. Lacroix, Carlos A. Villalba-Galea, Dirk Snyders, Francisco Bezanilla
Pages: 481 - 493