Researcher
Dirk Snyders
- Research Expertise:Electrophysiological analysis and Patch clamp.
- Keywords:STABLE CELL LINE GENERATION, PATCH-CLAMP, CHANNEL GATING, MOLECULAR CELL BIOLOGY OF ION CHANNELS, Biomedical sciences (incl. biochemistry)
- Disciplines:Medicinal and biomolecular chemistry, Molecular and cell biology, Plant biology, Systems biology, Biophysics, Cardiac and vascular medicine, Neurosciences, Physiology, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
- Research techniques:- Electrophysiological analysis - Patch clamp
- Users of research expertise:Pharmaceutical industry.
Affiliations
- Experimental Neurobiology Unit (ENU) (Research group)
Member
From1 Oct 2021 → Today - Molecular, Cellular and Network Excitability (MCNE) (Research group)
Responsible
From1 Jan 2020 → 30 Sep 2021 - Molecular, Cellular and Network Excitability (MCNE) (Research group)
Member
From1 Jan 2018 → 31 Dec 2019 - Molecular biophysics, physiology and pharmacology (Research group)
Responsible
From1 Oct 2003 → 31 Dec 2017
Projects
1 - 10 of 22
- Elucidating the pathogenicity of genetic variants of uncertain significance in Brugada syndrome patients by functional modelling in hiPSC-derived cardiomyocytes and zebrafish.From1 Nov 2020 → TodayFunding: FWO fellowships
- Multi-well microelectrode array (MEA): a bridge to highthroughput electrophysiology.From1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- A zebrafish model system to assess pathogenicity of genetic variants in patients with cardiac arrhythmias.From1 Jan 2020 → TodayFunding: FWO research project
- New and safer tools to cure cardiac arrhythmias through genetic-manipulation-free photothermal stimulation and enhanced photothermal ablation of cardiomyocytes.From1 Jan 2019 → 31 Oct 2019Funding: BOF - doctoral mandates
- Molecular elucidation of the unique gating behavior of cardiac ion channels thanks to their interaction with conopeptides.From1 Jan 2019 → 31 Dec 2022Funding: FWO research project
- Development of a functional assay to determine the pathogenicity of genetic variants with unknown significance identified in patients with cardiac arrhythmia.From1 Oct 2018 → 30 Sep 2022Funding: FWO fellowships
- Inherited cardiac arrhythmias: identification of novel genes and development of a new diagnostic tool for translating genetic diagnosis into precision medicine.From1 Jan 2017 → 31 Dec 2020Funding: BOF - Concerted Research Project from 1994
- "Silent" voltage-gated K+ channel subunits – no simple silent bystanders: analysis of their pharmacological profile, physiological role and gating mechanism.From1 Oct 2015 → 31 May 2016Funding: FWO fellowships
- The pharmacological profile of homomtetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels depends on the channel's inactivation gating.From1 Oct 2015 → 30 Jan 2017Funding: FWO fellowships
- Molecular architecture and assembly of heteromeric membrane proteins.From1 Jan 2015 → 31 Dec 2017Funding: Fund Recuperation Fiscal Exemption
Publications
1 - 10 of 53
- Clinical and functional characterisation of a recurrent KCNQ1 variant in the Belgian population(2023)
Authors: Ewa Sieliwonczyk, Maaike Alaerts, Eline Simons, Dirk Snyders, Aleksandra Nijak, Bert Vandendriessche, Dorien Schepers, Dogan Akdeniz, Emeline Van Craenenbroeck, Katleen Knaepen, et al.
Pages: 1 - 12 - Morpho-functional comparison of differentiation protocols to create iPSC-derived cardiomyocytes(2022)
Authors: Aleksandra Nijak, Eline Simons, Bert Vandendriessche, Dieter Van de Sande, Erik F P Fransen, Ewa Sieliwonczyk, Ilse Van Gucht, Emeline Van Craenenbroeck, Johan Saenen, Hein Heidbuchel, et al.
- Offsetting voltage-dependent Kv1.5 channel opening through charged residue substitutions on top of the first transmembrane segment(2022)
Authors: Kenny Van Theemsche, Joni G. Heymans, Nikola Z. Popovic, Evelyn Martinez Morales, Dirk Snyders, Alain J F E Labro
Pages: 160 - 167 - The nonconducting W434F mutant adopts upon membrane depolarization an inactivated-like state that differs from wild-type Shaker-IR potassium channels(2022)
Authors: Laura Coonen, Evelyn Martinez Morales, Dieter Van de Sande, Dirk Snyders, D. Marien Cortes, Luis G. Cuello, Alain J F E Labro
Pages: 1 - 11 - The resting membrane potential of hSC-CM in a syncytium is more hyperpolarised than that of isolated cells(2021)
Authors: Dieter Van de Sande, Ivan Kopljar, Maaike Alaerts, Ard Teisman, David J. Gallacher, Bart Loeys, Dirk Snyders, Luc Leybaert, Hua Rong Lu, Alain J F E Labro
Pages: 239 - 252 - Suitability of hSC and hiPSC derived cardiomyocytes as in vitro cell model that represents the physiological conditions for cardiotoxicity screening(2021)
Authors: Dieter Van de Sande, Dirk Snyders, Alain J F E Labro
Number of pages: 190 - Constitutive, basal, and beta-alanine-mediated activation of the human mas-related G protein-coupled receptor D induces release of the inflammatory cytokine IL-6 and is dependent on NF-kappa B signaling(2021)
Authors: Rohit Arora, Kenny Van Theemsche, Samuel Van Remoortel, Dirk Snyders, Alain J F E Labro, Jean-Pierre Timmermans
- The selectivity filter is involved in the U-type anactivation process of Kv2.1 and Kv3.1 channels(2020)
Authors: Laura Coonen, Evy Mayeur, Nicolas De Neuter, Dirk Snyders, Luis G. Cuello, Alain J F E Labro
Pages: 2612 - 2620 - Determining the correct stoichiometry of Kv2.1/Kv6.4 heterotetramers, functional in multiple stoichiometrical configurations(2020)
Authors: Lena Moller, Glenn Regnier, Alain J F E Labro, Rikard Blunck, Dirk Snyders
Pages: 9365 - 9376 - REPLY TO PISUPATI ET AL.: Evaluating single subunit counting data to find the correct stoichiometry(2020)
Authors: Lena Moeller, Glenn Regnier, Alain J F E Labro, Dirk Snyders, Rikard Blunck
Pages: 29290 - 29291