Researcher
Dean PAES
- Keywords:Biomedical sciences (incl. biochemistry)
- Disciplines:Genome structure and regulation, Cell growth and development, Cell signalling, Epigenetics, Genetics, Intracellular compartments and transport, Transcription and translation, Biomarker discovery, Compound screening, In vitro testing
Affiliations
- Neurosciences (Department)
Member
From1 Jan 2020 → Today - Neurosciences (Research group)
Member
From1 Jan 2020 → Today - Biomedical Research Institute (Research institute)
Member
From16 Jun 2017 → Today - Faculty of Medicine and Life Sciences (Faculty)
Member
From16 Jun 2017 → Today - Physiology - Biochemistry - Immunology (Department)
Member
From16 Jun 2017 → 31 Dec 2019 - Immunology - Biochemistry (Research group)
Member
From16 Jun 2017 → 31 Dec 2019
Publications
1 - 10 of 13
- Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-beta pathology(2023)
Authors: Dean PAES, Melissa SCHEPERS, Emily WILLEMS, Ben ROMBAUT, Assia TIANE, Yevgeniya Solomina, Amy Tibbo, Connor Blair, Elka Kyurkchieva, George S. Baillie, et al.
- Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis(2023)
Authors: Melissa SCHEPERS, Dean PAES, Assia TIANE, Ben ROMBAUT, Elisabeth PICCART, Lieve VAN VEGGEL, Pascal GERVOIS, Chiara Brullo, Olga Bruno, Ernesto Fedele, et al.
Pages: 1 - 22 - Picking the best isoform: PDE4D isoforms as therapeutic targets in Alzheimer's disease(2023)
Authors: Dean PAES, Tim VANMIERLO
Number of pages: 372 - Computational investigation of the dynamic control of cAMP signaling by PDE4 isoform types(2022)
Authors: Dean PAES, Sammy Hermans, Daniel van den Hove, Tim VANMIERLO, Jos Prickaerts, Aurelie Carlier
Pages: 2693 - 2711 - PDE inhibition in distinct cell types to reclaim the balance of synaptic plasticity(2021)
Authors: Ben ROMBAUT, Sofie KESSELS, Melissa SCHEPERS, Assia TIANE, Dean PAES, Yevgeniya Solomina, Elisabeth PICCART, Daniel van den Hove, Bert BRONE, Jos Prickaerts, et al.
Pages: 2080 - 2097 - Increased isoform-specific phosphodiesterase 4D expression is associated with pathology and cognitive impairment in Alzheimer’s disease(2021)
Authors: Dean PAES, Roy Lardenoije, Riccardo CAROLLO, Janou A. Y. Roubroeks, Melissa SCHEPERS, Paul Coleman, Diego Mastroeni, Elaine Delvaux, Ehsan Pishva, Katie Lunnon, et al.
Pages: 56 - 64 - The Molecular Biology of Phosphodiesterase 4 Enzymes as Pharmacological Targets: An Interplay of Isoforms, Conformational States, and Inhibitors(2021)
Authors: Dean PAES, Melissa SCHEPERS, Ben ROMBAUT, Daniel van den Hove, Tim VANMIERLO, Jos Prickaerts, Martin Michel
Pages: 1016 - 1049 - Pharmacological inhibition of phosphodiesterase 7 enhances consolidation processes of spatial memory(2021)
Authors: Susan McQuown, Dean PAES, Karsten Baumgartel, Jos Prickaerts, Marco Peters
- Relieving the epigenetic blockade in progressive multiple sclerosis - making remyelination accessible again(2019)
Authors: Assia TIANE, Melissa SCHEPERS, Dean PAES, J. Prickaerts, D. van den Hove, Niels HELLINGS, Tim VANMIERLO
Pages: E444 - E444 - Phosphodiesterase Type 4 Inhibition in CNS Diseases(2019)
Authors: A Blokland, P Heckman, Tim VANMIERLO, R Schreiber, Dean PAES, J Prickaerts
Pages: 971 - 985