Researcher
Davie Cappoen
- Keywords:Chemistry (incl. biochemistry)
- Disciplines:Analytical chemistry, Inorganic chemistry, Macromolecular and materials chemistry, Medicinal and biomolecular chemistry, Organic chemistry, Physical chemistry, Sustainable chemistry, Theoretical and computational chemistry, Other chemical sciences, Biochemistry and metabolism, Other biological sciences, Other natural sciences
Affiliations
- Laboratory for Microbiology, Parasitology and Hygiene (LMPH) (Research group)
Member
From1 Apr 2014 → 14 Nov 2022
Projects
1 - 9 of 9
- RNA biomarkers discovery for ultra-fast drug synergy and susceptibility testing in the mycobacterium avium complex.From1 Jan 2020 → 31 Oct 2020Funding: BOF - doctoral mandates
- Towards the realization of a structural biology platform at the University of Antwerp: The Mosquito Xtal3 crystallization robot as the missing link.From1 Jan 2020 → 31 Dec 2021Funding: BOF - scientific equipment program
- Exploitation of key enzymes of the mycothiol biosynthesis to improve treatment of mycobacterium avium complex infections.From1 Nov 2019 → 31 Oct 2023Funding: FWO Strategic Basic Research Grant
- Progress new assets (one pre-new molecular entity and one first-time-in-human start) for tuberculosis that act synergistically with bedaquiline, cytochrome bc or cytochrome bd inhibitors (RespiriTB).From1 May 2019 → TodayFunding: H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and wellbeing
- Development of a comprehensive platform for targeting redox homeostasis in Mycobacterium tuberculosis.From1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- Nanobody-assisted targeting of sialoadhesin-positive macrophages to improve the treatment of tuberculosis.From1 Oct 2017 → 30 Sep 2020Funding: FWO fellowships
- Elucidation of the octahydrobenzo[j]phenantridinediones as putitive redox cyclers in Mycobacterium tuberculosis.From1 Apr 2016 → 31 Mar 2017Funding: BOF - Other initiatives
- Biological evaluation of 1,3-diaryltriazenes and their mechanism of action on Mycobacterium tuberculosis.From1 Feb 2016 → 5 Jan 2020Funding: FWO Strategic Basic Research Grant
- Elucidating the mechanism of action of octahydrobenzo[j] phenanthridinediones as novel potent antimycobacterialcompounds.From1 Oct 2014 → 30 Sep 2017Funding: FWO fellowships
Publications
11 - 20 of 41
- Novel thiazolidinedione-hydroxamates as inhibitors of Mycobacterium tuberculosis virulence factor Zmp1(2020)
Authors: Veronika Slachtova, Marek Sebela, Eveline Torfs, Lauren Oorts, Davie Cappoen, Karel Berka, Vaclav Bazgier, Lucie Brulikova
- Optimization and characterization of a Galleria mellonella larval infection model for virulence studies and the evaluation of therapeutics against Streptococcus pneumoniae(2019)
Authors: Freya Cools, Eveline Torfs, Juliana Aizawa Porto de Abreu, Bieke Vanhoutte, Louis Maes, Guy Caljon, Peter Delputte, Davie Cappoen, Paul Cos
- 1-(Piperidin-3-yl)thymine amides as inhibitors of M. tuberculosis thymidylate kinase(2019)
Authors: Yanlin Jian, Martijn D.P. Risseeuw, Mathy Froeyen, Lijun Song, Davie Cappoen, Paul Cos, Hélène Munier-Lehmann, Serge van Calenbergh
Pages: 1730 - 1739 - In vitro biological investigation of novel anti-tubercular compound classes and the development of improved research tools(2019)
Authors: Eveline Torfs, Paul Cos, Davie Cappoen
Number of pages: 286 - Opportunities for overcoming mycobacterium tuberculosis drug resistance(2019)
Authors: Eveline Torfs, Paul Cos, Davie Cappoen
- The synthesis and in vitro biological evaluation of novel fluorinated tetrahydrobenzo[j]phenanthridine-7,12-diones against Mycobacterium tuberculosis(2019)
Authors: Davie Cappoen, Eveline Torfs, Tamara Meiresonne, Pieter Claes, Elena Semina, Francis Holvoet, Maira Bidart de Macedo, Freya Cools, An Matheeussen, Kevin Van Calster, et al.
- Synthesis and antitubercular activity of 1-and 3-substituted benzo[g]isoquinoline-5,10-diones(2019)
Authors: Robert Smets, Eveline Torfs, Filip Lemière, Paul Cos, Davie Cappoen, Kourosch Abbaspour Tehrani
Pages: 2923 - 2939 - Streptococcus pneumoniae galU gene mutation has a direct effect on biofilm growth, adherence and phagocytosis in vitro and pathogenicity in vivo(2018)
Authors: Freya Cools, Eveline Torfs, Bieke Vanhoutte, Maira Bidart de Macedo, L. Bonofiglio, M. Mollerach, Louis Maes, Guy Caljon, Peter Delputte, Davie Cappoen, et al.
- Identification of novel antitubercular agents from a mixed library comprised of plant extracts and heterocyclic compounds(2018)
Authors: Maira Bidart de Macedo, Paul Cos, Davie Cappoen
Number of pages: 177 - Synthesis and in vitro investigation of halogenated 1,3-bis(4-nitrophenyl)triazenide salts as antitubercular compounds(2018)
Authors: Eveline Torfs, Jure Vajs, Maira Bidart de Macedo, Freya Cools, Bieke Vanhoutte, Yury Gorbanev, Annemie Bogaerts, Luc Verschaeve, Guy Caljon, Peter Delputte, et al.
Pages: 631 - 640