Researcher
Claudia Spits
- Keywords:Medicine
- Disciplines:Stem cell biology, Reproductive medicine
Affiliations
- Reproduction and Genetics (Research group)
Member
From21 Jun 2010 → Today - Basic (bio-) Medical Sciences (Department)
Member
From1 Feb 2022 → Today - Basic (bio-) Medical Sciences (Department)
Member
From8 Apr 2019 → 31 Jan 2022 - Faculty of Medicine and Pharmacy (Faculty)
Member
From22 Jun 2017 → 7 Sep 2017 - Basic (bio-) Medical Sciences (Department)
Member
From1 Jan 2014 → 20 Oct 2022 - Basic (bio-) Medical Sciences (Department)
Member
From1 Jan 2014 → 31 Jan 2017 - Department of Embryology and Genetics (Department)
Member
From1 Oct 2011 → 31 Dec 2013 - Department of Embryology and Genetics (Department)
Member
From1 Jul 2002 → 31 Dec 2013
Projects
1 - 10 of 19
- Liver and brain organoids to model human pluripotent stem cell tumorigenesisFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- The Genetic Component to Infertility and Early Developmental FailureFrom1 Jan 2023 → TodayFunding: BOF - Methusalem
- The impact of chromosomal abnormalities in hPSC-derived retinal pigmented epithelial cellsFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- The impact of recurrent chromosomal abnormalities on growth advantage and differentiation capacity of human pluripotent stem cellsFrom1 Nov 2020 → TodayFunding: FWO fellowships
- Seahorse platform: the Agilent Seahorse Flux Analyser with integrated normalization systemFrom1 May 2020 → TodayFunding: Hercules - Small and Medium size research infrastructure
- The search for the origin of chromosomal abnormalities in human preimplantation embryosFrom1 Oct 2019 → 31 Oct 2023Funding: FWO fellowships
- A roadmap to the safe introduction of hESC in the clinic: the case of genetic mosaicism in hESC-derived retinal cellsFrom1 Jan 2019 → 31 Dec 2022Funding: FWO fellowships
- The origins of mitochondrial DNA mosaicism in early human developmentFrom1 Jan 2018 → 31 Dec 2018Funding: FWO research grant KAN
- The search for the origin of chromosomal abnormalities in human preimplantation embryosFrom1 Jan 2018 → 31 Dec 2021Funding: FWO research project (including WEAVE projects)
- Do children born after intracytoplasmic sperm injection have an increased risk of mutations in mitochondrial DNA?From1 Jan 2017 → 31 Dec 2017Funding: FWO research grant KAN
Publications
11 - 20 of 44
- The Impact of Acquired Genetic Abnormalities on the Clinical Translation of Human Pluripotent Stem Cells(2021)
Authors: Alexander Scott Keller, Claudia Spits
- The effect of polymorphisms in FSHR and FSHB genes on ovarian response(2021)
Authors: N. P. Polyzos, Ana Raquel Neves, Panagiotis Drakopoulos, Claudia Spits, B Alvaro Mercadal, Sergio Garcia, P Q M Ma, H. Le Treut, Manh Tuong Ho, Joke Mertens, et al.
Pages: 1711-1721 - Sustained intrinsic WNT and BMP4 activation impairs hESC differentiation to definitive endoderm and drives the cells towards extra-embryonic mesoderm(2021)
Authors: Christina Markouli, Edouard Couvreu De Deckersberg, Dominika Dziedzicka, Marius Regin, Silvie Franck, Alexander Scott Keller, Alexander Gheldof, Mieke Geens, Karen Sermon, Claudia Spits
- Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm(2021)
Authors: Dominika Dziedzicka, Mukul Tewary, Alexander Scott Keller, Laurentijn Tilleman, Laura Prochazka, Joel Östblom, Edouard Couvreu De Deckersberg, Christina Markouli, Silvie Franck, Filip Van Nieuwerburgh, et al.
- Uncovering low-level mosaicism in human embryonic stem cells using high throughput single cell shallow sequencing(2019)
Authors: Alexander Scott Keller, Laurentijn Tilleman, Dominika Dziedzicka, Filippo Zambelli, Karen Sermon, Filip Van Nieuwerburgh, Claudia Spits, Mieke Geens
- Gain of 20q11.21 in Human Pluripotent Stem Cells Impairs TGF-β-Dependent Neuroectodermal Commitment.(2019)
Authors: Christina Markouli, Edouard Couvreu De Deckersberg, Marius Regin, Ha Nguyen Thi, Filippo Zambelli, Alexander Scott Keller, Dominika Dziedzicka, Joery De Kock, Laurentijn Tilleman, Filip Van Nieuwerburgh, et al.
Pages: 163-176 - Losing Pluripotency. The impact of genomic alterations on differentiation.(2019)
Authors: Christina Markouli, Mieke Geens, Claudia Spits
- 243rd ENMC international workshop: Developing guidelines for management of reproductive options for families with maternally inherited mtDNA disease, Amsterdam, the Netherlands, 22-24 March 2019.(2019)
Authors: Joanna Poulton, Julie Steffann, J Burgstaller, R McFarland, B Arbeithuber, J Bengoa, S Chan, M Chiaratti, M Crouch, R Dimond, et al.
Pages: 725-733 - Human pluripotent stem cells in regenerative medicine(2018)
Authors: Ha Thi Nguyen, Kurt Jacobs, Claudia Spits
Pages: R143-R153 - Random Mutagenesis, Clonal Events, and Embryonic or Somatic Origin Determine the mtDNA Variant Type and Load in Human Pluripotent Stem Cells(2018)
Authors: Filippo Zambelli, Joke Mertens, Dominika Dziedzicka, Johan Sterckx, Christina Markouli, Alexander Scott Keller, Philippe Tropel, Laura Jung, Stephane Viville, Hilde Van de Velde, et al.
Pages: 102-114