Researcher
Christophe Pannecouque
- Keywords:Medicine
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Jul 2002 → Today
Projects
1 - 3 of 3 results
- An automated platform for multiparameter data collection on live pathogens of higher or unknown biosafety risk.From26 Jun 2014 → 31 Dec 2018Funding: Hercules - Large scale research infrastructure
- Identification of biomarkers and new therapeutic targets in HTLV-1-associated pathologies.From1 Jan 2010 → 31 Dec 2013Funding: FWO research project
- Mechanistic study on virus entry and replication. A fundamental approach to the development of new and specific antiviral chemotherapeutics.From1 Jan 2010 → 31 Dec 2014Funding: BOF - Concerted Research Project from 1994
Publications
1 - 10 of 291 results
- Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV-1 RNase H inhibitors.(2019)Journal: Chemical Biology & Drug DesignISSN: 1747-0277Issue: 4Volume: 93
Authors: Ping Gao, Xueshun Wang, Lin Sun, Xiqiang Cheng, Vasanthanathan Poongavanam, Jacob Kongsted, Mar Álvarez, Joanna Luczkowiak, Christophe Pannecouque, Erik De Clercq, et al.
Pages: 582 - 589 - Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors by exploring the structure-activity relationship of solvent-exposed regions I(2019)Journal: Chemical Biology & Drug DesignISSN: 1747-0277Issue: 4Volume: 93
Authors: Dongwei Kang, Zhao Wang, Meng Chen, Da Feng, Gaochan Wu, Zhongxia Zhou, Lanlan Jing, Xiaofang Zuo, Xiangyi Jiang, Dirk Daelemans, et al.
Pages: 430 - 437Number of pages: 8 - Targeting the hydrophobic channel of NNIBP: discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus.(2019)Journal: Organic & Biomolecular ChemistryISSN: 1477-0520Issue: 12Volume: 17
Authors: Zhongxia Zhou, Tao Liu, Gaochan Wu, Dongwei Kang, Zhipeng Fu, Zhao Wang, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Pages: 3202 - 3217 - Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles(2019)Journal: Journal of Medicinal ChemistryISSN: 0022-2623Issue: 4Volume: 62
Authors: Boshi Huang, Wenmin Chen, Tong Zhao, Zhenyu Li, Xiangyi Jiang, Tiziana Ginex, David Vilchez, Francisco Javier Luque, Dongwei Kang, Ping Gao, et al.
Pages: 2083 - 2098Number of pages: 16 - Identification of Dihydrofuro[3,4-d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties(2019)Journal: Journal of Medicinal ChemistryISSN: 0022-2623Issue: 3Volume: 62
Authors: Dongwei Kang, Heng Zhang, Zhao Wang, Tong Zhao, Tiziana Ginex, Francisco Javier Luque, Yang Yang, Gaochan Wu, Da Feng, Fenju Wei, et al.
Pages: 1484 - 1501Number of pages: 18 - Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs(2019)Journal: Bioorganic & Medicinal ChemistryISSN: 0968-0896Issue: 3Volume: 27
Authors: Zhao Wang, Zhao Yu, Dongwei Kang, Jian Zhang, Ye Tian, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Pages: 447 - 456Number of pages: 10 - From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors(2019)Journal: Journal of Enzyme Inhibition & Medicinal ChemistryISSN: 1475-6366Issue: 1Volume: 34
Authors: Serena Massari, Angela Corona, Simona Distinto, Jenny Desantis, Alessia Caredda, Stefano Sabatini, Giuseppe Manfroni, Tommaso Felicetti, Violetta Cecchetti, Christophe Pannecouque, et al.
Pages: 55 - 74Number of pages: 20 - Design and synthesis of a novel series of non-nucleoside HIV-1 inhibitors bearing pyrimidine and N-substituted aromatic piperazine(2018)Journal: Bioorganic & Medicinal Chemistry LettersISSN: 0960-894XIssue: 22Volume: 28
Authors: KaiJun Jin, YaLi Sang, Erik De Clercq, Christophe Pannecouque, Ge Meng
Pages: 3491 - 3495Number of pages: 5 - Design, synthesis, and antiviral evaluation of novel hydrazone-substituted thiophene[3,2-d]pyrimidine derivatives as potent human immunodeficiency virus-1 inhibitors(2018)Journal: Chemical Biology & Drug DesignISSN: 1747-0277Issue: 6Volume: 92
Authors: Zhao Wang, Dongwei Kang, Meng Chen, Gaochan Wu, Da Feng, Tong Zhao, Zhongxia Zhou, Zhipeng Huo, Lanlan Jing, Xiaofang Zuo, et al.
Pages: 2009 - 2021Number of pages: 13 - Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents(2018)Journal: Bioorganic & Medicinal Chemistry LettersISSN: 0960-894XIssue: 21Volume: 28
Authors: Konstantina Karypidou, Sergio Ribone, Mario A Quevedo, Leentje Persoons, Christophe Pannecouque, Christine Helsen, Frank Claessens, Wim Dehaen
Pages: 3472 - 3476Number of pages: 5