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Researcher
Christophe Pannecouque
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Jul 2002 → Today
Projects
1 - 3 of 3
- An automated platform for multiparameter data collection on live pathogens of higher or unknown biosafety risk.From26 Jun 2014 → 31 Dec 2018Funding: Hercules - Large scale research infrastructure
- Mechanistic study on virus entry and replication. A fundamental approach to the development of new and specific antiviral chemotherapeutics.From1 Jan 2010 → 31 Dec 2014Funding: BOF - Concerted Research Project from 1994
- Identification of biomarkers and new therapeutic targets in HTLV-1-associated pathologies.From1 Jan 2010 → 31 Dec 2013Funding: FWO research project
Publications
1 - 10 of 353
- Contemporary Medicinal Chemistry Strategies for the Discovery and Development of Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors(2022)
Authors: Christophe Pannecouque, Erik De Clercq
Pages: 3729 - 3757Number of pages: 29 - Discovery of Novel Pyridine-Dimethyl-Phenyl-DAPY Hybrids by Molecular Fusing of Methyl-Pyrimidine-DAPYs and Difluoro-Pyridinyl-DAPYs: Improving the Druggability toward High Inhibitory Activity, Solubility, Safety, and PK.(2022)
Authors: Christophe Pannecouque, Erik De Clercq
Pages: 2122 - 2138 - Indolylarylsulfones bearing phenylboronic acid and phenylboronate ester functionalities as potent HIV-1 non-nucleoside reverse transcriptase inhibitors(2022)
Authors: Christophe Pannecouque
Number of pages: 11 - Boronic acid-containing diarylpyrimidine derivatives as novel HIV-1 NNRTIs: Design, synthesis and biological evaluation(2021)
Authors: Christophe Pannecouque
Pages: 4053 - 4057Number of pages: 5 - Deciphering the Role of Extracellular Vesicles Derived from ZIKV-Infected hcMEC/D3 Cells on the Blood-Brain Barrier System(2021)
Authors: Antonios Fikatas, Jonas Dehairs, Johannes Swinnen, Christophe Pannecouque, Dominique Schols
Number of pages: 20 - Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability(2021)
Authors: Christophe Pannecouque
Number of pages: 16 - Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors(2021)
Authors: Christophe Pannecouque
Number of pages: 18 - Design of the naphthyl-diarylpyrimidines as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) via structure-based extension into the entrance channel(2021)
Authors: Christophe Pannecouque, Erik De Clercq
Number of pages: 15 - Design, synthesis, and antiviral evaluation of novel piperidine-substituted arylpyrimidines as HIV-1 NNRTIs by exploring the hydrophobic channel of NNIBP(2021)
Authors: Christophe Pannecouque
Number of pages: 12 - Structure-Based Design and Discovery of Pyridyl-Bearing Fused Bicyclic HIV-1 Inhibitors: Synthesis, Biological Characterization, and Molecular Modeling Studies(2021)
Authors: Dirk Daelemans, Erik De Clercq, Christophe Pannecouque
Pages: 13604 - 13621Number of pages: 18