Researcher
Christophe Pannecouque
- Keywords:Medicine
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Jul 2002 → Today
Projects
1 - 3 of 3 results
- An automated platform for multiparameter data collection on live pathogens of higher or unknown biosafety risk.From26 Jun 2014 → 31 Dec 2018Funding: Hercules - Large scale research infrastructure
- Identification of biomarkers and new therapeutic targets in HTLV-1-associated pathologies.From1 Jan 2010 → 31 Dec 2013Funding: FWO research project
- Mechanistic study on virus entry and replication. A fundamental approach to the development of new and specific antiviral chemotherapeutics.From1 Jan 2010 → 31 Dec 2014Funding: BOF - Concerted Research Project from 1994
Publications
1 - 10 of 303 results
- Pharmacophore-fusing design of pyrimidine sulfonylacetanilides as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.(2020)Journal: Bioorganic ChemistryISSN: 0045-2068Volume: 96
Authors: Yali Sang, Christophe Pannecouque, Erik De Clercq, Chunlin Zhuang, Fener Chen
Pages: 103595 - Indazolyl-substituted piperidin-4-yl-aminopyrimidines as HIV-1 NNRTIs: Design, synthesis and biological activities.(2020)Journal: European Journal of Medicinal ChemistryISSN: 0223-5234Volume: 186
Authors: Ting Xiao, Jia-Fan Tang, Ge Meng, Christophe Pannecouque, Yuan-Yuan Zhu, Gen-Yan Liu, Zhi-Qiang Xu, Feng-Shou Wu, Shuang-Xi Gu, Fen-Er Chen
Pages: 111864 - Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors(2020)Journal: European Journal of Medicinal ChemistryISSN: 0223-5234Volume: 185
Authors: Sheng Han, Yali Sang, Yan Wu, Yuan Tao, Christophe Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen-Er Chen
Number of pages: 13 - Ligand-Based Design of Nondimethylphenyl-Diarylpyrimidines with Improved Metabolic Stability, Safety, and Oral Pharmacokinetic Profiles(2019)Journal: Journal of Medicinal ChemistryISSN: 0022-2623Issue: 24Volume: 62
Authors: Yali Sang, Sheng Han, Christophe Pannecouque, Erik De Clercq, Chunlin Zhuang, Fener Chen
Pages: 11430 - 11436Number of pages: 7 - Conformational restriction design of thiophene-biphenyl-DAPY HIV-1 non-nucleoside reverse transcriptase inhibitors(2019)Journal: European Journal of Medicinal ChemistryISSN: 0223-5234Volume: 182
Authors: Yali Sang, Sheng Han, Christophe Pannecouque, Erik De Clercq, Chunlin Zhuang, Fener Chen
Number of pages: 12 - Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing(2019)Journal: European Journal of Medicinal ChemistryISSN: 0223-5234Volume: 182
Authors: Tong Zhao, Qing Meng, Dongwei Kang, Jianbo Ji, Erik De Clercq, Christophe Pannecouque, Xinyong Liu, Peng Zhan
Number of pages: 16 - Overview of Recent Strategic Advances in Medicinal Chemistry(2019)Journal: Journal of Medicinal ChemistryISSN: 0022-2623Issue: 21Volume: 62
Authors: Gaochan Wu, Tong Zhao, Dongwei Kang, Jian Zhang, Yuning Song, Vigneshwaran Namasivayam, Jacob Kongsted, Christophe Pannecouque, Erik De Clercq, Vasanthanathan Poongavanam, et al.
Pages: 9375 - 9414Number of pages: 40 - Molecular design opportunities presented by solvent-exposed regions of target proteins(2019)Journal: Medicinal Research ReviewsISSN: 0198-6325Issue: 6Volume: 39
Authors: Xiangyi Jiang, Ji Yu, Zhongxia Zhou, Jacob Kongsted, Yuning Song, Christophe Pannecouque, Erik De Clercq, Dongwei Kang, Vasanthanathan Poongavanam, Xinyong Liu, et al.
Pages: 2194 - 2238Number of pages: 45 - Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H, 3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase(2019)Journal: Bioorganic & Medicinal ChemistryISSN: 0968-0896Issue: 17Volume: 27
Authors: Ping Gao, Xiqiang Cheng, Lin Sun, Shu Song, Mar Alvarez, Joanna Luczkowiak, Christophe Pannecouque, Erik De Clercq, Luis Menendez-Arias, Peng Zhan, et al.
Pages: 3836 - 3845Number of pages: 10 - Synthesis and biological evaluation of dihydroquinazoline-2-amines as potent non-nucleoside reverse transcriptase inhibitors of wild-type and mutant HIV-1 strains(2019)Journal: European Journal of Medicinal ChemistryISSN: 0223-5234Volume: 176
Authors: KaiJun Jin, YaLi Sang, Sheng Han, Erik De Clercq, Christophe Pannecouque, Ge Meng, FenEr Chen
Pages: 11 - 20Number of pages: 10