Researcher
Christophe Pannecouque
- Keywords:Medicine
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Jul 2002 → Today
Projects
1 - 3 of 3 results
- An automated platform for multiparameter data collection on live pathogens of higher or unknown biosafety risk.From26 Jun 2014 → 31 Dec 2018Funding: Hercules - Large scale research infrastructure
- Identification of biomarkers and new therapeutic targets in HTLV-1-associated pathologies.From1 Jan 2010 → 31 Dec 2013Funding: FWO research project
- Mechanistic study on virus entry and replication. A fundamental approach to the development of new and specific antiviral chemotherapeutics.From1 Jan 2010 → 31 Dec 2014Funding: BOF - Concerted Research Project from 1994
Publications
1 - 10 of 297 results
- Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H, 3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase(2019)Journal: Bioorganic & Medicinal ChemistryISSN: 0968-0896Issue: 17Volume: 27
Authors: Ping Gao, Xiqiang Cheng, Lin Sun, Shu Song, Mar Alvarez, Joanna Luczkowiak, Christophe Pannecouque, Erik De Clercq, Luis Menendez-Arias, Peng Zhan, et al.
Pages: 3836 - 3845Number of pages: 10 - Synthesis and biological evaluation of dihydroquinazoline-2-amines as potent non-nucleoside reverse transcriptase inhibitors of wild-type and mutant HIV-1 strains(2019)Journal: European Journal of Medicinal ChemistryISSN: 0223-5234Volume: 176
Authors: KaiJun Jin, YaLi Sang, Sheng Han, Erik De Clercq, Christophe Pannecouque, Ge Meng, FenEr Chen
Pages: 11 - 20Number of pages: 10 - Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing.(2019)Journal: European Journal of Medicinal ChemistryISSN: 0223-5234Volume: 182
Authors: Tong Zhao, Qing Meng, Dongwei Kang, Jianbo Ji, Erik De Clercq, Christophe Pannecouque, Xinyong Liu, Peng Zhan
Pages: 111619 - Conformational restriction design of thiophene-biphenyl-DAPY HIV-1 non-nucleoside reverse transcriptase inhibitors.(2019)Journal: European Journal of Medicinal ChemistryISSN: 0223-5234Volume: 182
Authors: Yali Sang, Sheng Han, Christophe Pannecouque, Erik De Clercq, Chunlin Zhuang, Fener Chen
Pages: 111603 - Follow on-based optimization of the biphenyl-DAPYs as HIV-1 nonnucleoside reverse transcriptase inhibitors against the wild-type and mutant strains(2019)Journal: Bioorganic ChemistryISSN: 0045-2068Volume: 89
Authors: Yali Sang, Sheng Han, Shuwen Han, Christophe Pannecouque, Erik De Clercq, Chunlin Zhuang, Fener Chen
Number of pages: 9 - Discovery of piperidine-substituted thiazolo[5,4-d] pyrimidine derivatives as potent and orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitors(2019)Journal: Communications ChemistryVolume: 2
Authors: Dongwei Kang, Tong Zhao, Zhao Wang, Da Feng, Heng Zhang, Boshi Huang, Gaochan Wu, Fenju Wei, Zhongxia Zhou, Lanlan Jing, et al.
Number of pages: 8 - Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors by exploring the structure-activity relationship of solvent-exposed regions I(2019)Journal: Chemical Biology & Drug DesignISSN: 1747-0277Issue: 4Volume: 93
Authors: Dongwei Kang, Zhao Wang, Meng Chen, Da Feng, Gaochan Wu, Zhongxia Zhou, Lanlan Jing, Xiaofang Zuo, Xiangyi Jiang, Dirk Daelemans, et al.
Pages: 430 - 437Number of pages: 8 - Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV-1 RNase H inhibitors(2019)Journal: Chemical Biology & Drug DesignISSN: 1747-0277Issue: 4Volume: 93
Authors: Ping Gao, Xueshun Wang, Lin Sun, Xiqiang Cheng, Vasanthanathan Poongavanam, Jacob Kongsted, Mar Alvarez, Joanna Luczkowiak, Christophe Pannecouque, Erik De Clercq, et al.
Pages: 582 - 589Number of pages: 8 - Targeting the hydrophobic channel of NNIBP: discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus(2019)Journal: Organic & Biomolecular ChemistryISSN: 1477-0520Issue: 12Volume: 17
Authors: Zhongxia Zhou, Tao Liu, Gaochan Wu, Dongwei Kang, Zhipeng Fu, Zhao Wang, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Pages: 3202 - 3217Number of pages: 16 - Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles(2019)Journal: Journal of Medicinal ChemistryISSN: 0022-2623Issue: 4Volume: 62
Authors: Boshi Huang, Wenmin Chen, Tong Zhao, Zhenyu Li, Xiangyi Jiang, Tiziana Ginex, David Vilchez, Francisco Javier Luque, Dongwei Kang, Ping Gao, et al.
Pages: 2083 - 2098Number of pages: 16