Researcher
Christophe Pannecouque
- Keywords:Medicine
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Jul 2002 → Today
Projects
1 - 3 of 3 results
- An automated platform for multiparameter data collection on live pathogens of higher or unknown biosafety risk.From26 Jun 2014 → 31 Dec 2018Funding: Hercules - Large scale research infrastructure
- Identification of biomarkers and new therapeutic targets in HTLV-1-associated pathologies.From1 Jan 2010 → 31 Dec 2013Funding: FWO research project
- Mechanistic study on virus entry and replication. A fundamental approach to the development of new and specific antiviral chemotherapeutics.From1 Jan 2010 → 31 Dec 2014Funding: BOF - Concerted Research Project from 1994
Publications
1 - 10 of 322 results
- Identification of novel potent HIV-1 inhibitors by exploiting the tolerant regions of the NNRTIs binding pocket.(2021)
Authors: Yanying Sun, Dongwei Kang, Feng Da, Tao Zhang, Pei Li, Baodan Zhang, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Pages: 113204 - Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties.(2021)
Authors: Xiangyi Jiang, Boshi Huang, Fisayo A Olotu, Jing Li, Dongwei Kang, Zhao Wang, Erik De Clercq, Mahmoud ES Soliman, Christophe Pannecouque, Xinyong Liu, et al.
Pages: 113051 - Design, synthesis, and evaluation of “dual-site”-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase(2021)
Authors: D Feng, X Zuo, L Jing, C Chen, FA Olotu, H Lin, M Soliman, Erik De Clercq, Christophe Pannecouque, K Lee, et al.
Number of pages: 16 - Novel indolylarylsulfone derivatives as covalent HIV-1 reverse transcriptase inhibitors specifically targeting the drug-resistant mutant Y181C(2021)
Authors: Ping Gao, Shu Song, Estrella Frutos-Beltran, Wenxin Li, Bin Sun, Dongwei Kang, Jinmi Zou, Jian Zhang, Christophe Pannecouque, Erik De Clercq, et al.
Number of pages: 11 - Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility(2020)
Authors: Zhao Wang, Dongwei Kang, Da Feng, Srinivasulu Cherukupalli, Xiangyi Jiang, Zhipeng Fu, Erik De Clercq, Christophe Pannecouque, Xinyong Liu, Peng Zhan
Number of pages: 17 - Bioisosterism-based design and enantiomeric profiling of chiral hydroxyl-substituted biphenyl-diarylpyrimidine nonnucleoside HIV-1 reverse transcriptase inhibitors(2020)
Authors: Xiaomei Chen, Li Ding, Yuan Tao, Christophe Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen-Er Chen
Number of pages: 13 - Discovery of potential dual-target prodrugs of HIV-1 reverse transcriptase and nucleocapsid protein 7(2020)
Authors: Songkai Sun, Boshi Huang, Zhuo Li, Zhao Wang, Lin Sun, Ping Gao, Dongwei Kang, Chin-Ho Chen, Kuo-Hsiung Lee, Dirk Daelemans, et al.
Number of pages: 5 - Structure-Activity Relationship Exploration of NNIBP Tolerant Region I Leads to Potent HIV-1 NNRTIs(2020)
Authors: Dongwei Kang, Yanying Sun, N Arul Murugan, Da Feng, Fenju Wei, Jing Li, Xiangyi Jiang, Erik De Clercq, Christophe Pannecouque, Peng Zhan, et al.
Pages: 2225 - 2234Number of pages: 10 - Design, synthesis, and biological evaluation of piperidinyl-substituted [1,2,4]triazolo[1,5-a]pyrimidine derivatives as potential anti-HIV-1 agents with reduced cytotoxicity(2020)
Authors: Boshi Huang, Dongwei Kang, Ye Tian, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Pages: 67 - 76Number of pages: 10 - Privileged scaffold inspired design of novel oxime-biphenyl-DAPYs in treatment of HIV-1(2020)
Authors: Yang Yang, Christophe Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen-Er Chen
Number of pages: 10