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Researcher
Chris Ulens
- Disciplines:Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
Affiliations
- Laboratory of Structural Neurobiology (Division)
Responsible
From1 Jan 2012 → Today - Laboratory of Structural Neurobiology (Division)
Member
From1 Oct 2007 → Today - Toxicology and Pharmacology (Division)
Member
From1 Oct 1999 → 31 Jan 2004
Projects
1 - 10 of 30
- Structural and functional studies of ligand-activated insect ion channels for the development of safer insecticidesFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Structural and functional characterisation of the Myzus persicae nicotinic acetylcholine receptors for the development of safer agricultural pesticidesFrom1 Oct 2023 → TodayFunding: FWO junior postdoctoral fellowship
- Molecular mechanism of insect pentameric ligand-gated ion channels as a target for new insecticidesFrom1 Oct 2023 → TodayFunding: Fund Recuperation Fiscal Exemption, BOF - projects
- Development of nanobodies as a strategy to neutralize neurotoxins in envenomation by poisonous snakebites.From12 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- A broad-spectrum antidote against venomous snakebites based on engineering of nicotinic acetylcholine receptors and derivatives.From1 Nov 2021 → TodayFunding: FWO junior postdoctoral fellowship
- Molecular mechanism of the honeybee nicotinic acetylcholine receptor, the target for neonic insecticidesFrom1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- A 200 kV transmission electron microscope for high-resolution determination of 3D-ultrastructure of native proteins, cells and tissueFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Crystallographic facility for target-based drug designFrom1 May 2020 → TodayFunding: FWO International research infrastructure (IRI)
- Development of a powerful antidote against lethal neurotoxic snakebites using the naturally occurring acetylcholine binding protein (AChBP) as a decoy receptor.From1 Oct 2019 → 30 Sep 2022Funding: IOF - technology validation in lab
Publications
51 - 60 of 60
- From structure and function analysis in AChBP to drug design(2013)
Authors: AB Smit, Chris Ulens
Pages: 184 - 184 - Structure of NPP1, an Ectonucleotide Pyrophosphatase/Phosphodiesterase Involved in Tissue Calcification(2012)
Authors: Silvia Jansen, Chris Ulens, Claudia Winkler, Maria Andries, Frank Luyten, Mathieu Bollen
Pages: 1948 - 1959 - Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines(2012)
Authors: Radovan Spurny, Chris Ulens
Pages: E3028 - E3034 - Insights into the Structural Determinants Required for High-Affinity Binding of Chiral Cyclopropane-Containing Ligands to α4β2-Nicotinic Acetylcholine Receptors: An Integrated Approach to Behaviorally Active Nicotinic Ligands(2012)
Authors: Mieke Nys, Chris Ulens
Pages: 8028 - 8037 - The pharmacological profile of ELIC, a prokaryotic GABA-gated receptor(2012)
Authors: Chris Ulens
Pages: 761 - 767 - Molecular actions of smoking cessation drugs at α4β2 nicotinic receptors defined in crystal structures of a homologous binding protein(2012)
Authors: Bert Billen, Radovan Spurny, Thomas Voets, Chris Ulens
Pages: 9173 - 9178 - Structural Principles of Serotonin and Granisetron Recognition in a 5-HT3/Binding Protein Chimera(2012)
Authors: Divya Kesters, Marijke Brams, Radovan Spurny, Rene van Elk, Andrew Thompson, Matthis Geitmann, Albert Guskov, Helena Danielson, Sarah Lummis, August Smit, et al.
Pages: 112A - 112A - Allosteric Modulators Targeting Multiple Binding Sites in Bacterial Homolog of GABAA Receptor(2012)
Authors: Radovan Spurny, Bert Billen, Marijke Brams, Rebecca Howard, Adron R Harris, Chris Ulens
Pages: 111 - A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and d-Tubocurarine by Different Cys-Loop Receptors(2011)
Authors: Chris Ulens
- Crystal Structures of a Cysteine-modified Mutant in Loop D of Acetylcholine-binding Protein(2011)
Authors: Steve Peigneur, Jan Tytgat, Sergei Strelkov, Chris Ulens
Pages: 4420 - 4428