Researcher
Chris Ulens
- Disciplines:Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
Affiliations
- Laboratory of Structural Neurobiology (Division)
Responsible
From1 Jan 2012 → Today - Laboratory of Structural Neurobiology (Division)
Member
From1 Oct 2007 → Today - Toxicology and Pharmacology (Division)
Member
From1 Oct 1999 → 31 Jan 2004
Projects
1 - 10 of 30
- Structural and functional studies of ligand-activated insect ion channels for the development of safer insecticidesFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Structural and functional characterisation of the Myzus persicae nicotinic acetylcholine receptors for the development of safer agricultural pesticidesFrom1 Oct 2023 → TodayFunding: FWO junior postdoctoral fellowship
- Molecular mechanism of insect pentameric ligand-gated ion channels as a target for new insecticidesFrom1 Oct 2023 → TodayFunding: Fund Recuperation Fiscal Exemption, BOF - projects
- Development of nanobodies as a strategy to neutralize neurotoxins in envenomation by poisonous snakebites.From12 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- A broad-spectrum antidote against venomous snakebites based on engineering of nicotinic acetylcholine receptors and derivatives.From1 Nov 2021 → TodayFunding: FWO junior postdoctoral fellowship
- Molecular mechanism of the honeybee nicotinic acetylcholine receptor, the target for neonic insecticidesFrom1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- A 200 kV transmission electron microscope for high-resolution determination of 3D-ultrastructure of native proteins, cells and tissueFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Crystallographic facility for target-based drug designFrom1 May 2020 → TodayFunding: FWO International research infrastructure (IRI)
- Development of a powerful antidote against lethal neurotoxic snakebites using the naturally occurring acetylcholine binding protein (AChBP) as a decoy receptor.From1 Oct 2019 → 30 Sep 2022Funding: IOF - technology validation in lab
Publications
21 - 30 of 60
- Allosteric Modulation of the Pentameric Ligand-Gated Ion Channel ELIC by Functionally Active Nanobodies(2018)
Authors: Marijke Brams, Hannelore De Peuter, Radovan Spurny, Els Pardon, Daniel Bertrand, Jan Steyaert, Cedric Govaerts, Chris Ulens
Pages: 298A - 298A - Biochemical Characterization of the Interaction of TRPM3 with G(beta gamma) Proteins(2018)
Authors: Fabian Gruss, Marc Behrendt, Mieke Nys, Johannes Oberwinkler, Chris Ulens
Pages: 642A - 642A - Allosteric Modulation of the Pentameric Ligand-Gated Ion Channel ELIC by Barbiturates(2018)
Authors: Hannelore De Peuter, Marijke Brams, Delphine Joseph, Daniel Bertrand, Chris Ulens
Pages: 300A - 300A - An allosteric binding site of the alpha 7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein(2018)
Authors: Fabian Gruss, Sam Noppen, Steve Peigneur, Patrick Chaltin, Sandra Liekens, Jan Tytgat, Chris Ulens
Pages: 2534 - 2545 - Crystal structure of the pentameric ligand-gated ion channel ELIC in complex with a nanobody active as an allosteric modulator(2017)
Authors: M Brams, R Spurny, K Price, E Pardon, D Bertrand, S Lummis, J Steyaert, C Govaerts, Chris Ulens
Pages: 23 - 23 - Functional Characterization of a Nicotinic Acetylcholine Receptor from an Extremophile Worm(2017)
Authors: Eveline Wijckmans, Florian Delbart, Chris Ulens
Pages: 552A - 552A - Palonosetron-5-HT3 Receptor Interactions As Shown by a Binding Protein Cocrystal Structure(2016)
Authors: Chris Ulens
Pages: 1641 - 1646 - Functional and Biochemical Characterization of Alvinella pompejana Cys-Loop Receptor Homologues(2016)
Authors: Eveline Wijckmans, Mieke Nys, Chris Ulens
- Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine(2016)
Authors: Mieke Nys, Eveline Wijckmans, Radovan Spurny, Steve Peigneur, Jan Tytgat, Chris Ulens
Pages: E6696 - E6703 - Structural hot spots for the solubility of globular proteins(2016)
Authors: Aleksandra Siekierska, Joost Van Durme, Greet De Baets, Rob van der Kant, Rodrigo Gallardo, Tobias Langenberg, Frederik De Smet, Chris Ulens, Frederic Rousseau, Joost Schymkowitz
Pages: 10816 - 10816