Researcher
Catherine Verfaillie
- Disciplines:Genetics, Systems biology, Molecular and cell biology
Affiliations
- Stem Cell and Developmental Biology (Division)
Member
From1 Apr 2013 → 30 Sep 2022
Infrastructure
1 - 1 of 1
- Platform for Next Generation Screening in Quantitative Biology & Drug Discovery (Consortium coordinator)
Projects
1 - 10 of 95
- Business development of a drug screening Spin-off company based on 2D & 3D human iPSC-derived liver cell models for NASH & (i)DILI.From1 Aug 2021 → 31 Jan 2022Funding: IOF - mandates
- RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3RsFrom1 Jun 2021 → TodayFunding: H2020 - Health, demographic change and wellbeing
- Robotized Human Liver-Mimic 3D Model Platform for Efficient NAFLD and DILI Compound ScreeningFrom1 Jan 2021 → 31 Dec 2022Funding: IOF - technology validation in lab
- Advanced 3D Complex Tissues BioAssembly Platform for Precision Disease Modeling, Drug Discovery and Regenerative Medicine (3D-BioBOT)From1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- In vitro functional formation of liver sinusoidal endothelial cells in 3D culture system.From1 Oct 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- iPSC-based parenchymal and sinusoidal liver cell mimics for DILI and NAFLD studies (iPSC-LiMic)From1 Oct 2020 → TodayFunding: FWO Strategic Basic Research (SBO)
- Drug discovery for Parkinson’s disease using a translational screening platformFrom1 Oct 2020 → 31 Mar 2024Funding: IOF - technology validation in lab
- OrganID: Organ-derived complex 2D/3D cultures in human diseaseFrom1 Oct 2020 → TodayFunding: FWO Strategic Basic Research (SBO)
- Proof of concept: immunotherapy in glioblastoma multiforme.From21 Sep 2020 → TodayFunding: FWO fellowships
- 3D-PADchip: Engineering 3D Perfusable human "Alzheimer's Disease (AD)-On-Chip ModelFrom28 Aug 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
11 - 20 of 375
- Genetically Engineered Triple MAPT-Mutant Human-Induced Pluripotent Stem Cells (N279K, P301L, and E10+16 Mutations) Exhibit Impairments in Mitochondrial Bioenergetics and Dynamics(2023)
Authors: Catherine Verfaillie
- CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity(2023)
Authors: Wenting Guo, Elke Braems, Pegah Masrori, Evelien Van Schoor, Maarten Jacquemyn, Sriram Balusu, Tine Tricot, Pieter Vanden Berghe, Dietmar Thal, Rik Vandenberghe, et al.
Pages: 1245 - 1259 - The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency(2023)
Authors: Paraskevi ATHANASOULI, Ben van der Veer, Tijs Vanhessche, Kian Koh, Vincent Pasque, Catherine Verfaillie, An Zwijsen, Frederic Lluis Vinas
- The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency(2023)
Authors: Paraskevi ATHANASOULI, Ben van der Veer, Tijs Vanhessche, Vincent Pasque, Catherine Verfaillie, An Zwijsen, Frederic Lluis Vinas
- Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis(2023)
Authors: Esther Wolfs, Catherine Verfaillie
Pages: 1 - 22 - Large-scale perfused tissues via synthetic 3D soft microfluidics(2023)
Authors: Anja Vananroye, Idris Salmon, Catherine Verfaillie, Adrian Ranga
- The global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation(2023)
Authors: Marino Caruso, Catherine Verfaillie
Pages: 254 - 268 - Advances in Recellularization of Decellularized Liver Grafts with Different Liver (Stem) Cells: Towards Clinical Applications(2023)
Authors: Catherine Verfaillie
- A FACILE METHOD TO GENERATE CEREBRAL ORGANOIDS FROM HUMAN PLURIPOTENT STEM CELLS(2023)
Authors: San Kit To, Vincent Pasque, Tim Vervliet, Yoke Chin Chai, Catherine Verfaillie
Pages: 1055 - 1076 - Microbiota, not host origin drives ex vivo intestinal epithelial responses(2022)
Authors: Kaline Arnauts, Padhmanand Sudhakar, Sare Verstockt, Bram Verstockt, Jeroen Raes, Séverine Vermeire, João Guedelha Sabino, Catherine Verfaillie, Marc Ferrante
Patents
1 - 10 of 10
- Methods for differentiating cells into hepatic stellate cells (Inventor)
- Hydrogels for cell culture (Inventor)
- Nek6 inhibition to treat als and ftd (Inventor)
- Spheroidal self-assembled peptide hydrogels comprising cells (Inventor)
- Methods for differentiating cells into hepatic stellate cells (Inventor)
- Cell culture media for differentiation of stem cells into hepatocytes (Inventor)
- Methods for identifying activators and suppressors (Inventor)
- Stem cell aggregates and methods for making and using (Inventor)
- Cell therapy for myelodysplastic syndromes (Inventor)
- Optimized methods for differentiation of cells into cells with hepatocyte and hepatocyte progenitor phenotypes, cells produced by the methods, and methods for using the cells (Inventor)