Researcher
Bruno De Geest
- Keywords:immunology, polymer chemistry, Nanomedicine
- Disciplines:Biopharmaceutics, Adaptive immunology, Cancer therapy, Innate immunity, Synthesis of materials, Chemistry of clusters, colloids and nanomaterials, Macromolecular and materials chemistry not elsewhere classified, Animal immunology, Vaccines, Vaccinology
Affiliations
- Department of Pharmaceutics (Department)
Member
From1 Oct 2003 → Today
Projects
1 - 10 of 63
- DEXTRACs: An innovative concept for targeted degradation of extracellular proteinsFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Development of an innovative Fentanyl vaccineFrom20 Dec 2023 → TodayFunding: IOF - technology validation in lab
- MATRACs / Membrane Anchoring Trafficking ChimerasFrom1 Nov 2023 → TodayFunding: FWO fellowships
- HEPTAMETHINE CYANINE-POLY(ETHYLENE GLYCOL) AS MOLECULAR ANCHOR FOR TUMOR TARGETED CYTOKINE DELIVERYFrom1 Oct 2023 → TodayFunding: FWO senior postdoctoral fellowship
- MACYCs / Membrane Anchoring CYtokine ChimeraS: Unlocking the full potential of tumor acidity for tumor-targeted cytokine delivery.From1 Oct 2023 → TodayFunding: BOF - doctoral mandates
- A translational cancer vaccination approach based on co-delivery of tumor antigen and Toll-like receptor agonistsFrom1 Jan 2023 → TodayFunding: Foundations, funds and other with scientific goal
- BOF-ZAP professorship biopharamaceutical technologyFrom1 Jan 2023 → TodayFunding: BOF - ZAP BOF mandates
- MITACS: Multivalent Immune TArgeting synthetic Chimeric therapeuticS.From1 Jan 2023 → TodayFunding: BOF - iBOF
- Introducing mRNA vaccination in chicken: first steps towards a commercial mRNA vaccine against a leading viral infection in chickenFrom1 Nov 2022 → TodayFunding: IOF - technology validation in lab
- A pre-targeted nanomedicine strategy for in vivo CD8+ T cell engineering.From1 Nov 2022 → TodayFunding: FWO fellowships
Publications
41 - 50 of 213
- Tumor engineering a clinical relevant model that recapitulates the tumor environment of peritoneal metastases in vitro and in vivo(2019)
Authors: Elly De Vlieghere, Emiel De Jaeghere, Glenn Wagemans, Thibaut Van Acker, Christian Vanhove, Geert Berx, Frank Vanhaecke, Wim Ceelen, Bruno De Geest, Heidi Declercq, et al.
Number of pages: 1 - Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists(2019)
Authors: Jana De Vrieze, Benoit Louage, Kim Deswarte, Zifu Zhong, Ruben De Coen, Simon Van Herck, Lutz Nuhn, Camilla Kaas Frich, Alexander N Zelikin, Stefan Lienenklaus, et al.
Pages: 15390 - 15395 - Efficient innate immune killing of cancer cells triggered by cell-surface anchoring of multivalent antibody-recruiting polymers(2019)
Authors: Annemiek Uvyn, Ruben De Coen, Mandy Gruijs, Cees W. Tuk, Jana De Vrieze, Marjolein van Egmond, Bruno De Geest
Pages: 12988 - 12993 - Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells(2019)
Authors: Annemiek Uvyn, Ruben De Coen, Kim Deswarte, Bruno De Geest
Pages: 10952 - 10955 - A synthetic, transiently thermoresponsive homopolymer with UCST behaviour within a physiologically relevant window(2019)
Authors: Zhiyue Zhang, Hui Li, Sabah Kasmi, Simon Van Herck, Kim Deswarte, Richard Hoogenboom, Lutz Nuhn, Bruno De Geest
Pages: 7866 - 7872 - Immunoengineering through cancer vaccines - A personalized and multi-step vaccine approach towards precise cancer immunity(2018)
Authors: Lien Lybaert, Karim Vermaelen, Bruno De Geest, Lutz Nuhn
Pages: 125 - 145 - The relevance of shear, sedimentation and diffusion during spin freezing, as potential first step of a continuous freeze-drying process for unit doses(2018)
Authors: Joris Lammens, Séverine Mortier, Laurens De Meyer, Brecht Vanbillemont, Pieter-Jan Van Bockstal, Simon Van Herck, Jos Corver, Ingmar Nopens, Valérie Vanhoorne, Bruno De Geest, et al.
Pages: 1 - 10 - Nanoparticle-conjugate TLR7/8 agonist localized immunotherapy provokes safe antitumoral responses(2018)
Authors: Lutz Nuhn, Stefaan De Koker, Francis Combes, Kim Deswarte, Yupeng Li, Stefan Lienenklaus, Niek Sanders, Sunil A David, Jan Tavernier, Bruno De Geest
- Recombinant ferritin-H induces immunosuppression in European sea bass larvae (Dicentrarchus labrax) rather than immunostimulation and protection against a Vibrio anguillarum infection(2018)
Authors: Bruno De Geest, Jens Goethals, Aline Bajek, Kristof Dierckens
Pages: 19 - 27 - Targeting protumoral tumor-associated macrophages with nanobody-functionalized nanogels through strain promoted azide alkyne cycloaddition ligation(2018)
Authors: Lutz Nuhn, Evangelia Bolli, Sam Massa, Isabel Vandenberghe, Kiavash Movahedi, Bart Devreese, Jo A Van Ginderachter, Bruno De Geest
Pages: 2394 - 2405