Researcher
Bart Vandekerckhove
- Keywords:Advanced therapy medicinal products, GMP, immunotherapy
- Disciplines:Other medical and health sciences not elsewhere classified, Adaptive immunology, Medicinal products not elsewhere classified, Cancer therapy
Affiliations
- Department of Diagnostic Sciences (Department)
Member
From1 Oct 2018 → Today - Department of Clinical chemistry, microbiology and immunology (Department)
Member
From1 Jan 1993 → 30 Sep 2018
Projects
1 - 10 of 30
- Chromatography for the purification of in vitro transcribed RNA as part of the production process of lipid nanoparticle vaccines and cancer immunotherapeutics for use in clinical trials (C-puRNA)From20 Dec 2023 → TodayFunding: IOF - technology validation in lab
- Chimeric antigen receptor unconventional T cell therapy (CAR-uT) for the treatment of solid tumorsFrom1 Nov 2023 → TodayFunding: FWO junior postdoctoral fellowship
- Optimisation of CD70-targeted adoptive cell therapyFrom1 Nov 2023 → TodayFunding: FWO Strategic Basic Research Grant
- ABSL3 mice housing system to develop new therapies against virulent pathogensFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- Optimising CD70-specific T cell therapy for solitary and haematological malignanciesFrom1 Nov 2022 → 31 Oct 2023Funding: BOF - doctoral mandates
- Chimeric antigen receptor unconventional T cell therapy (CAR-uT) for the treatment of solid tumorsFrom1 Nov 2022 → TodayFunding: FWO Strategic Basic Research Grant
- Patient-friendly tumor sampling for the design, and reduction of the production time of a neoepitope dendritic cell vaccine for patients presenting with inoperable non small cell lung carcinoma (NEO4LUNG)From1 Oct 2022 → TodayFunding: Nonprofit institution or equivalents
- CARTAGENA- Development of an innovative platform and complementary assays for screening and selection of CAR-T cellsFrom15 Jul 2022 → TodayFunding: IOF - technology validation in lab
- A patient derived xenograft (PDX) platform for in vivo evaluation of novel anticancer therapiesFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- White light laser-based confocal fluorescence lifetime imaging microscope for multi-parameter 3D live imagingFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
Publications
1 - 10 of 34
- Gene editing-based targeted integration for correction of Wiskott-Aldrich syndrome(2024)
Authors: Melissa Pille, John M. Avila, So Hyun Park, Cuong Q. Le, Haipeng Xue, Filomeen Haerynck, Lavanya Saxena, Ciaran Lee, Elizabeth J. Shpall, Gang Bao, et al.
- Single-cell profiling identifies a novel human polyclonal unconventional T cell lineage(2023)
Authors: Lore Billiet, Laurenz De Cock, Guillem Sanchez Sanchez, Rupert Mayer, Glenn Goetgeluk, Stijn De Munter, Melissa Pille, Joline Ingels, Hanne Jansen, Karin Weening, et al.
- Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF(2023)
Authors: Kai Ling Liang, Juliette Roels, Marieke Lavaert, Tom Putteman, Lena Böhme, Laurentijn Tilleman, Imke Velghe, Valentina Pegoretti, Inge Van de Walle, Stephanie Sontag, et al.
Pages: 474 - 486 - Transcriptional dynamics and epigenetic regulation of E and ID protein encoding genes during human T cell development(2022)
Authors: Juliette Roels, Jolien Van Hulle, Marieke Lavaert, Anna Kuchmiy, Steven Strubbe, Tom Putteman, Bart Vandekerckhove, Georges Leclercq, Filip Van Nieuwerburgh, Lena Böhme, et al.
- In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality(2021)
Authors: Sarah Bonte, Stijn De Munter, Lore Billiet, Glenn Goetgeluk, Joline Ingels, Hanne Jansen, Melissa Pille, Laurenz De Cock, Karin Weening, Tom Taghon, et al.
- A novel non-coding variant in DCLRE1C results in deregulated splicing and induces SCID through the generation of a truncated ARTEMIS protein that fails to support V(D)J recombination and DNA damage repair(2021)
Authors: Steven Strubbe, Marieke De Bruyne, Ulrich Pannicke, Elien Beyls, Bart Vandekerckhove, Georges Leclercq, Elfride De Baere, Victoria Bordon, Anne Vral, Klaus Schwarz, et al.
- Conventional and computational flow cytometry analyses reveal sustained human intrathymic T cell development from birth until puberty(2020)
Authors: Marieke Lavaert, Bart Vandekerckhove, Georges Leclercq, Kai Ling Liang, Tom Taghon
- Intracellular delivery of mRNA in adherent and suspension cells by vapor nanobubble photoporation(2020)
Authors: Laurens Raes, Stephan Stremersch, Juan Fraire, Toon Brans, Glenn Goetgeluk, Stijn De Munter, Lien Van Hoecke, Rein Verbeke, Jelter Van Hoeck, Ranhua Xiong, et al.
- Human thymic CD10+ PD-1+ intraepithelial lymphocyte precursors acquire interleukin-15 responsiveness at the CD1a– CD95+ CD28– CCR7– developmental stage(2020)
Authors: Lore Billiet, Glenn Goetgeluk, Sarah Bonte, Stijn De Munter, Laurenz De Cock, Melissa Pille, Joline Ingels, Hanne Jansen, Karin Weening, Filip Van Nieuwerburgh, et al.
- T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources(2020)
Authors: Sarah Bonte, Stijn De Munter, Glenn Goetgeluk, Joline Ingels, Melissa Pille, Lore Billiet, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre