Researcher
Alejandro Sifrim
- Disciplines:Genetics, Systems biology, Molecular and cell biology, Medical imaging and therapy, Other paramedical sciences
Affiliations
- Laboratory of Multi-omic Integrative Bioinformatics (Division)
Responsible
From1 Sep 2020 → Today - Department of Human Genetics (Department)
Member
From1 Sep 2020 → Today - Dynamical Systems, Signal Processing and Data Analytics (STADIUS) (Division)
Member
From1 Aug 2020 → 16 Oct 2016 - Laboratory of Reproductive Genomics (Division)
Member
From17 Oct 2016 → 31 Aug 2020
Projects
1 - 10 of 13
- Single-cell and spatial multi-omics for biomedicineFrom1 Oct 2022 → TodayFunding: IOF - mandates
- Single-objective light sheet instrument for fast and highthroughput imaging of 3D tissueFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Development of multimodal deep neural networks for spatial multi-omics data fusionFrom1 Oct 2021 → TodayFunding: FWO fellowships
- COLUMBO: Engineered CRISPR toolbox for revolutionizing single-cell genome imaging in embryogenesis and oncologyFrom1 Oct 2021 → TodayFunding: BOF - projects
- Automated characterization of cellular morphology and subcellular expression patterns using spatial transcriptomics and deep neural networksFrom1 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Disease Mechanisms in ALS [a Single Nuclei Sequencing Study of Patient-derived Material]From22 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Novel computational methods for characterizing cell state and cell-cell interactions using spatial transcriptomics with an AI-assisted experimental designFrom12 Jul 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Bioinformatics for single-cell sequence and in situ RNA analytics to study cell niches and cell-cell interactionFrom10 May 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Resolving cellular heterogeneity and cooperation in human health and disease using highly multiplexed spatial (multi-)omics technologiesFrom25 Sep 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Development of an interdisciplinary platform for spatial multi-omic analysis of single cellsFrom1 Oct 2019 → TodayFunding: BOF - projects
Publications
1 - 10 of 43
- Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease(2021)
Authors: Jeroen Breckpot, Alejandro Sifrim, Koenraad Devriendt, Bernard Thienpont
- The contribution of X-linked coding variation to severe developmental disorders(2021)
Authors: Alejandro Sifrim
- Systems genetics analysis identifies calcium-signaling defects as novel cause of congenital heart disease(2020)
Authors: Alejandro Sifrim, Bernard Thienpont, Jeroen Breckpot, Marc Gewillig
- Heterotypic cell-cell communication regulates glandular stem cell multipotency(2020)
Authors: Alejandro Sifrim, Thierry Voet
Pages: 608 - + - Mechanisms of stretch-mediated skin expansion at single-cell resolution(2020)
Authors: Alejandro Sifrim, Thierry Voet
Pages: 268 - + - Interstitial Cell Remodeling Promotes Aberrant Adipogenesis in Dystrophic Muscles(2020)
Authors: Natacha Breuls, Alejandro Sifrim, Nefele Giarratana, Marlies Corvelyn, Sebastiaan Vanuytven, Rik Gijsbers, Thierry Voet, Maurilio Sampaolesi
- Defining the Design Principles of Skin Epidermis Postnatal Growth(2020)
Authors: Alejandro Sifrim, Thierry Voet
Pages: 604 - + - Contribution of retrotransposition to developmental disorders(2019)
Authors: Alejandro Sifrim
- Heterozygous Variants in KMT2E Cause a Spectrum of Neurodevelopmental Disorders and Epilepsy(2019)
Authors: Anne H O'Donnell-Luria, Lynn S Pais, Victor Faundes, Jordan C Wood, Abigail Sveden, Victor Luria, Rami Abou Jamra, Andrea Accogli, Kimberly Amburgey, Britt Marie Anderlid, et al.
Pages: 1210 - 1222 - CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language (vol 9, 4619, 2018)(2019)
Authors: Lot Snijders Blok, Justine Rousseau, Joanna Twist, Sophie Ehresmann, Motoki Takaku, Hanka Venselaar, Lance H Rodan, Catherine B Nowak, Jessica Douglas, Kathryn J Swoboda, et al.