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Researcher

Abraham Lin

  • Research interest:I am a Postdoctoral Researcher at the University of Antwerp in the field of non-thermal plasma medicine. My research aims to understand plasma-cell interactions and develop non-thermal plasma systems for biomedical applications. Topics of Investigation:1) Electrical and chemical characterization of plasma treatment regimes for biological applications (e.g. cancer immunotherapy, surface decontamination, neuroregeneration)2) Development of plasma devices and systems for medical applications including robotics and neural network integration3) Modulation of tumor-expressing immunosuppressive signals via wet lab experiments and computational modelling4) Plasma-induced intracellular pathways for sensitivity and resistance development via cancer bioinformatics tools5) Plasma effects on immunogenic cell death (ICD), tumor microenvironment (TME), epithelial–mesenchymal transition (EMT), and metastasis6) Combination cancer therapies with plasma7) Plasma-induced cell death mechanisms
  • Keywords:NON-THERMAL PLASMA MEDICINE, APPLIED PHYSICS, PLASMA CHEMISTRY, BIOMEDICAL ENGINEERING, Chemistry (incl. biochemistry)
  • Disciplines:Analytical chemistry, Medicinal and biomolecular chemistry, Physical chemistry, Other chemical sciences, Biochemistry and metabolism, Other biological sciences, Other natural sciences, Nuclear physics not elsewhere classified, Physics of (fusion) plasmas and electric discharges, Physics of gases, plasmas and electric discharges not elsewhere classified, Biomaterials engineering not elsewhere classified, Medical biotechnology not elsewhere classified, Adaptive immunology, Innate immunity, Cancer therapy
  • Research techniques:1) Non-thermal plasma device operations2) Detection of reactive oxygen species using electron paramagnetic resonance (EPR) spectroscopy, colorimetric assays, UV-Vis spectrophotometry.3) Power measurements of high voltage plasma systems.4) 2D (monolayer) and 3D cell culture using spheroids or the live avian egg model5) In vitro wet lab work and assays including flow cytometry, tissue immunohistochemistry, and image-based analysis with the Incucyte and Tecan Spark Cyto6) In vivo work with murine cancer models (FELAS C certified)7) Cancer bioinformatics8) Robotics development and control
  • Users of research expertise:1) Chemists2) Plasma physicists3) Oncologists and clinicians4) Biomedical engineers5) Medical device companies6) Robotics and computer engineers