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Synthesis and evaluation of amino-modified U+03B1-GalCer analogues

Journal Contribution - Journal Article

Subtitle:Synthesis and evaluation of amino-modified alpha-GalCer analogues
alpha-GalCer analogues featuring a phytoceramide 3- and 4-amino group have been synthesized. A Mitsunobu reaction involving phthalimide was employed for the introduction of the amino groups at the 3- and 4-positions of suitable phytosphingosine-derived precursors. The influence of these modifications on the interaction with the T-cell receptor of NKT cells was investigated, as well as the capacity of the amino-modified analogues to induce a cytokine response after in vivo administration.
Journal: Organic Letters
ISSN: 1523-7060
Issue: 13
Volume: 12
Pages: 2928 - 2931
Publication year:2010
Keywords:Organic & medicinal chemistry