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Scarless excision of an insertion sequence restores capsule production and virulence in Acinetobacter baumannii

Journal Contribution - Journal Article

We identify a new mechanism mediating capsule production and virulence in the WHO and CDC priority ESKAPE pathogen Acinetobacter baumannii. Non-capsulated and avirulent bacteria can revert into a capsulated and virulent state upon scarless excision of an ISAba13 insertion sequence under stress conditions. Reversion events fully restore capsule production and in vivo virulence. This increases our knowledge about A. baumannii genome dynamics, and the regulation of capsule production, virulence and resistance.
Journal: The ISME journal : multidisciplinary journal of microbial ecology
ISSN: 1751-7362
Volume: 99
Publication year:2021
Keywords:A1 Journal article