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Rapid construction of substituted 3-amino-1,5-benzothiazepin-4(5H)-one dipeptide scaffolds through an Ugi-4CR - Ullmann cross-coupling sequence. IF 3.49

Journal Contribution - Journal Article

A 3-step methodology for the synthesis of 1,5-benzothiazepin-4(5H)-one dipeptidomimetics has been elaborated via an Ugi-4CR followed by a S-trityl deprotection and an intramolecular Cu(i)-catalyzed Ullmann condensation with moderate to good yields. In silico and NMR conformational studies showed that the lowest energy conformers stabilize γ- and β-turn structures.

Journal: Organic & Biomolecular Chemistry
ISSN: 1477-0520
Issue: 8
Volume: 16
Pages: 1242-1246
Publication year:2018
BOF-publication weight:1
CSS-citation score:1
Authors from:Higher Education