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Publication

Pretargeted PET Imaging Using a Bioorthogonal 18F‑Labeled trans- Cyclooctene in an Ovarian Carcinoma Model

Journal Contribution - Journal Article

In cancer research, pretargeted positron emission tomography (PET) imaging has emerged as an effective two-step approach that combines the excellent target affinity and selectivity of antibodies with the advantages of using short-lived radionuclides such as fluorine-18. One possible approach is based on the bioorthogonal inverse-electron-demand Diels-Alder (IEDDA) reaction between tetrazines and trans-cyclooctene (TCO) derivatives. Here, we report the first successful use of an 18F-labeled small TCO compound, [18F]1 recently developed in our laboratory, to perform pretargeted immuno-PET imaging. The study was performed in an ovarian carcinoma mouse model, using a trastuzumab-tetrazine conjugate.
Journal: Bioconjugate Chemistry
ISSN: 1043-1802
Issue: 12
Volume: 28
Pages: 2915 - 2920
Publication year:2017
Keywords:Biochemistry/biophysics/molecular biology, Multidisciplinary chemistry, Organic & medicinal chemistry