THE POTENTIAL OF STEM CELLS IN TACKLING NEURODEGENERATIVE DISEASES

© 2017 Elsevier Inc. All rights reserved. In the second part of this chapter, we will discuss adult neurogenesis in the context of neurodegeneration and the possible use of this stem cells source as a therapeutic target. Both in mammals as in humans, neurogenesis persists during adulthood in two germinal regions: the subventricular zone of the lateral ventricles and the dentate gyrus in the hippocampus. In neurodegenerative diseases, this neurogenesis cascade is impaired and might account for some of the presented preclinical symptoms. Hence, harnessing this endogenous stem cell pool as a therapeutic target might tackle the progressive neurodegeneration and alleviate some of these symptoms.

ISBN:978-0-12-805120-7

Publication year:2017