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Patient-reported outcome measures on mental health and psychosocial factors in patients with Brugada syndrome

Journal Contribution - Journal Article

AIMS: Brugada syndrome (BrS) is a hereditary arrhythmic disease, associated with sudden cardiac death. To date, little is known about the psychosocial correlates and impacts associated with this disease. The aim of this study was to assess a set of patient-reported psychosocial outcomes, to better profile these patients, and to propose a tailored psychosocial care.

METHODS AND RESULTS: Patients were recruited at the European reference Centre for BrS at Universitair Ziekenhuis Brussel, Belgium. Recruitment was undertaken in two phases: phase 1 (retrospective), patients with confirmed BrS, and phase 2 (prospective), patients referred for ajmaline testing who had an either positive or negative diagnosis. BrS patients were compared to controls from the general population. Two hundred and nine questionnaires were analysed (144 retrospective and 65 prospective). Collected patient-reported outcomes were on mental health (12 item General Health Questionnaire; GHQ-12), social support (Oslo Social Support Scale), health-related quality of life, presence of Type-D personality (Type-D Scale; DS14), coping styles (Brief-COPE), and personality dimensions (Ten Item Personality Inventory). Results showed higher mental distress (GHQ-12) in BrS patients (2.53 ± 3.03) than in the general population (P < 0.001) and higher prevalence (32.7%) of Type D personality (P < 0.001) in patients with confirmed Brugada syndrome (BrS +). A strong correlation was found in the BrS + group (0.611, P < 0.001) between DS14 negative affectivity subscale and mental distress (GHQ-12).

CONCLUSION: Mental distress and type D personality are significantly more common in BrS patients compared to the general population. This clearly illustrates the necessity to include mental health screening and care as standard for BrS.

Journal: Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
ISSN: 1099-5129
Issue: 9
Volume: 25
Pages: 1-10
Publication year:2023
Keywords:Humans, Brugada Syndrome/diagnosis, Mental Health, Prospective Studies, Retrospective Studies, Quality of Life, Patient Reported Outcome Measures, Electrocardiography/methods
  • ORCID: /0000-0003-3584-6818/work/153030813
  • PubMed Central Id: PMC10540670
  • PubMed Id: 37772950
  • WoS Id: 001077827300003
  • DOI: https://doi.org/10.1093/europace/euad205
  • ORCID: /0000-0001-9769-1511/work/143660438
  • ORCID: /0000-0002-6193-2296/work/143660079
  • ORCID: /0000-0003-3460-4251/work/143659841
  • ORCID: /0000-0001-9912-7121/work/143659830
  • ORCID: /0000-0001-8583-1994/work/143657182
  • ORCID: /0000-0001-6713-823X/work/143656210
  • ORCID: /0000-0003-3906-758X/work/143655801
  • ORCID: /0000-0002-8035-2887/work/143654782
  • ORCID: /0000-0001-6346-4564/work/143654324
  • Scopus Id: 85173566084
  • Institutional Repository URL: https://cris.vub.be/ws/files/105990472/105270245.pdf