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Opportunities for overcoming mycobacterium tuberculosis drug resistance

Journal Contribution - e-publication

Subtitle:emerging mycobacterial targets and host-directed therapy
The ever-increasing incidence of drug-resistant Mycobacterium tuberculosis infections has invigorated the focus on the discovery and development of novel treatment options. The discovery and investigation of essential mycobacterial targets is of utmost importance. In addition to the discovery of novel targets, focusing on non-lethal pathways and the use of host-directed therapies has gained interest. These adjunctive treatment options could not only lead to increased antibiotic susceptibility of Mycobacterium tuberculosis, but also have the potential to avoid the emergence of drug resistance. Host-directed therapies, on the other hand, can also reduce the associated lung pathology and improve disease outcome. This review will provide an outline of recent opportunities.
Journal: International journal of molecular sciences
ISSN: 1422-0067
Volume: 20
Publication year:2019
Keywords:A1 Journal article
BOF-publication weight:1
CSS-citation score:2
Authors from:Higher Education