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Neuroserpin of Macaca Fascicularis – Identification, Sequence and Structural Analyses in Silico

Journal Contribution - Journal Article

Neuroserpin, a clade of serpins, is a family of serineprotease inhibitors (>220 residues), and is a selective inhibitor of tissuetype plasminogen activator (tPA) in humans. Neuroserpin has been well elucidated in humans, on the otherhand, identification of this serpin has not been accomplished in non-human primates so far. As neuroserpin plays an important role in the memory and learning processes in humans, the presence of neuroserpin in the non-human primates has been suspected. Thus, this study has been devised to identify the presence of neuroserpin in Macaca fascicularis, to associate the similarities between the human and Macaca fascicularis (Mfas) neuroserpin and also to discriminate the structural differences between them. The structural organization of the motifs have also been analyzed for their intact conservation patterns.
Journal: International Journal on Recent Trends in Engineering and Technology
ISSN: 2158-5555
Issue: 1
Volume: 4
Pages: 80 - 82
Publication year:2010