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Mosquito transgenesis for malaria control

Journal Contribution - Review Article

Malaria is one of the deadliest diseases. Because of the ineffectiveness of current malaria-control methods, several novel mosquito vector-based control strategies have been proposed to supplement existing control strategies. Mosquito transgenesis and gene drive have emerged as promising tools for preventing the spread of malaria by either suppressing mosquito populations by self-destructing mosquitoes or replacing mosquito populations with disease-refractory populations. Here we review the development of mosquito transgenesis and its application for malaria control, highlighting the transgenic expression of antiparasitic effector genes, inactivation of host factor genes, and manipulation of miRNAs and lncRNAs. Overall, from a malaria-control perspective, mosquito transgenesis is not envisioned as a stand-alone approach; rather, its use is proposed as a complement to existing vector-control strategies.

Journal: Trends In Parasitology
ISSN: 1471-4922
Issue: 1
Volume: 38
Pages: 54-66
Publication year:2022
Keywords:Animals, Anopheles/physiology, Gene Transfer Techniques, Malaria/parasitology, Mosquito Control, Mosquito Vectors/genetics