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Mechanisms underlying connexin hemichannel activation in disease

Journal Contribution - Journal Article

Gap junctions and connexin hemichannels mediate intercellular and extracellular commu-nication, respectively. While gap junctions are seen as the “good guys” by controlling homeostasis, connexin hemichannels are considered as the “bad guys”, as their activation is associated with the onset and dissemination of disease. Open connexin hemichannels indeed mediate the transport of messengers between the cytosol and extracellular environment and, by doing so, fuel inflammation and cell death in a plethora of diseases. The present mini-review discusses the mechanisms involved in the activation of connexin hemichannels during pathology.

Journal: International Journal of Molecular Sciences
ISSN: 1661-6596
Issue: 7
Volume: 22
Pages: 1-13
Publication year:2021
Keywords:connexin hemichannel, pathology, mechanism
BOF-keylabel:yes
IOF-keylabel:yes
BOF-publication weight:1
Authors:Regional
Authors from:Higher Education
Accessibility:Open