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Maximizing content across scales: Moving multimodal microscopy and mesoscopy toward molecular imaging

Journal Contribution - Journal Article

Molecular imaging aims to depict the molecules in living patients. However, because this aim is still far beyond reach, patchworks of different solutions need to be used to tackle this overarching goal. From the vast toolbox of imaging techniques, we focus on those recent advances in optical microscopy that image molecules and cells at the submicron to centimeter scale. Mesoscopic imaging covers the "imaging gap" between techniques such as confocal microscopy and magnetic resonance imagingthat image entire live samples but with limited resolution. Microscopy focuses on the cellular level; mesoscopy visualizes the organization of molecules and cells into tissues and organs. The correlation between these techniques allows us to combine disciplines ranging from whole body imaging to basic research of model systems. We review current developments focused on improving microscopic and mesoscopic imaging technologies and on hardware and software that push the current sensitivity and resolution boundaries.
Journal: Current Opinion in Chemical Biology
ISSN: 1367-5931
Volume: 63
Pages: 188 - 199
Number of pages: 12
Publication year:2021
Keywords:Biochemistry/biophysics/molecular biology