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Publication
Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge
Journal Contribution - Journal Article
Microglia respond as brain macrophages robustly to serum cytokine exposure but rapidly restore quiescence. Here, Shemer et al. establish the requirement of leukocyte-derived IL-10 to prevent fatal microglia hyperactivation and secretion of otherwise detrimental microglial TNF.
Journal: Immunity
ISSN: 1074-7613
Issue: 5
Volume: 53
Pages: 1033-1049
Publication year:2020
Keywords:Cx3cr1, IL-10, LPS, LTP, Microglia activation, TNF, conditional mutagenesis, sepsis, sickness behavior, tamoxifen
CSS-citation score:2
Accessibility:Open