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Interesting antifungal drug targets in the central metabolism of Candida albicans

Journal Contribution - Journal Article

To treat infections caused by Candida albicans, azoles, polyenes, and echinocandins are used. However, resistance occurs against all three, so there is an urgent need for new antifungal drugs with a novel mode of action. Recently, it became clear that central metabolism plays an important role in the virulence of C. albicans. Glycolysis is, for example, upregulated during virulence conditions, whereas the glyoxylate cycle is important upon phagocytosis by host immune cells. These findings indicate that C. albicans adapts its metabolism to the environment for maximal virulence. In this review, we provide an overview of the potency of different central metabolic pathways and their key enzymes as potential antifungal drug targets.
Journal: Trends in Pharmacological Sciences
ISSN: 0165-6147
Issue: 1
Volume: 43
Pages: 69 - 79
Publication year:2022
Accessibility:Closed