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Interaction patches of Procaspase-1 Caspase Recruitment Domains (CARDs) are differently involved in Procaspase-1 Activation and Receptor-interacting Protein 2 (RIP2)-dependent nuclear factor κB signaling

Journal Contribution - Journal Article

Background: The CARD of procaspase-1 regulates activation of procaspase-1 and NF-kappa B. Results: We show that the CARD procaspase-1 interacts with ASC through a type I interaction, whereas RIP2-mediated NF-kappa B activation involves a type III interaction. Conclusion: These findings indicate that the CARD of procaspase-1 is differently involved in inflammasome formation and NF-kappa B activation. Significance: These findings may allow development of therapeutics that specifically target a procaspase-1 function.
Journal: Journal of biological chemistry
ISSN: 0021-9258
Volume: 286
Pages: 35874 - 35882
Publication year:2011
Keywords:A1 Journal article
Accessibility:Closed