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Highly Diastereoselective Synthesis of 1-Carbamoy1-4-aminoindoloazepinone Derivatives via the Ugi Reaction

Journal Contribution - Journal Article

Subtitle:IF 6.324

A one-pot procedure for the highly diastereoselective synthesis of 1-carbamoy1-4-amino-1,2,4,5-tetrahydroindolo[2,3-c]azepin-3-one derivatives is described. Using 2-formyk-tryptophan as a bifunctional building block, a catalyst-free Ugi-three-component reaction (Ugi-3CR) was developed to present trisubstituted indoloazepinones in good yields and excellent diastereomeric excess.
Journal: Org.Lett.
ISSN: 1523-7060
Issue: 22
Volume: 15
Pages: 5866-5869
Publication year:2013
Keywords:stereoselective 4-component condensations, multicomponent reactions, drug discovery, isosyanides, alpha, chemistry, potent, construction, antagonists, lactams
  • Scopus Id: 84887865143