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Freeform beam shaping optics for large-size 3D scaffold fabrication with high accuracy

Book Contribution - Book Chapter Conference Contribution

Three-dimensional (3D) bioprinting approaches that enable large-scale constructs and high-resolution simultaneously are
very attractive to tissue engineering applications and health industries. However, both characteristics hardly meet at
reasonable printing times in current 3D bioprinting technologies, affecting the introduction of 3D scaffolds in medical
applications. To overcome this limitation, we recently introduced a vat photopolymerization (VP)-based bioprinting
method named light sheet stereolithography (LS-SLA) and demonstrated the fabrication of centimeter-scale scaffolds with
micrometer-scale features (> 13 μm) by using off-the-shelf optical compounds. The high performance in LS-SLA results
from using a rectangular uniform beam instead of a rotational symmetric laser beam, which generates light sheets with
large length-to-width aspect ratios on the vat film. Beam shaping optics are components used to perform the beam
transformation, and guarantee the accuracy, uniformity, and size of the 3D constructs. This work proposes freeform optics
to perform the laser beam shaping in the LS-SLA device and describes the progress of our investigations from design to
proof-of-concept-demonstrating. The results show that rectangular beams are readily produced by freeform optics resulting
in compact and energy efficient systems, and that further considerations on the real laser output are necessary to deliver
high beam uniformities. Tackling the design challenges of this work leads to energy efficient and high accuracy LS-SLA
Book: Optical Methods for Inspection, Characterization, and Imaging of Biomaterials VI
Series: Proceedings of SPIE - The International Society for Optical Engineering
Volume: 12622
Pages: 1-9
Number of pages: 9
Publication year:2023
Keywords:Tissue engineering, 3D Printing, Bioprinting, Scaffold, Biocompatible, Light sheet