DNA methylation of insulin-like growth factor 2 and H19 cluster in cord blood and prenatal air pollution exposure to fine particulate matter

Background: The IGF2 (insulin-like growth factor 2) and H19 gene cluster plays an important role during pregnancy as it promotes both foetal and placental growth. We investigated the association between cord blood DNA methylation status of the IGF2/H19 gene cluster and maternal fine particulate matter exposure during fetal life. To the best of our knowledge, this is the first study investigating the association between prenatal PM 2.5 exposure and newborn DNA methylation of the IGF2/H19.

Publication year:2020

Keywords:Air pollution, DLNM, Factor analysis, Fetal growth, Gestation, H19, IGF2, Imprinted genes, Methylation, Newborn, PM2.5

BOF-keylabel:yes

IOF-keylabel:yes

BOF-publication weight:3

CSS-citation score:1

Authors:International

Authors from:Higher Education

Accessibility:Open