Divergent synthetic approach to 6''-modified U+03B1-GalCer analogues

Subtitle:Divergent synthetic approach to 6 ''-modified alpha-GalCer analogues

A synthetic approach is presented for the synthesis of galacturonic acid and D-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6 ''-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6 ''-modified KRN7000 analogues.