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Distal esophageal spasm and the Chicago classification

Journal Contribution - Journal Article

Subtitle:is timing everything?
Background According to the Chicago classification of esophageal motility disorders, distal esophageal spasm (DES) is defined as premature esophageal contractions (distal latency [DL] < 4.5s) for >= 20% of swallows, in the presence of a normal mean integral relaxation pressure (IRP). However, some patients with symptoms of DES have rapid contractions with a normal DL. The aim of this study was to characterize these patients and compare their clinical characteristics to those of patients classified as DES. Methods We retrospectively compared clinical characteristics and high-resolution manometry findings of patients with rapid contractions with normal latency to those meeting the Chicago classification criteria for DES. Key Results Over a 3-year period, nine patients were diagnosed with DES and 14 showed rapid contractions in the distal esophagus with normal latency. The latter were younger than DES patients (60 +/- 4 vs 72 +/- 3years, p < 0.05). Dysphagia and retrosternal pain occurred to a similar degree in both groups. Weight loss and abnormal barium esophagogram tended to be more frequent in DES patients. There was no difference in contractile front velocity (CFV) and in distal contractile integral (DCI) between patients with DES and rapid contractions with normal latency. Lower esophageal sphincter pressures were not different between groups. However, IRP was significantly higher in DES compared to rapid contractions with normal latency (11.7 +/- 0.6 mmHg vs 7.6 +/- 1.2mmHg, p <0.05), albeit still within the normal range. Conclusions & InferencesThese data suggest that patients with simultaneous contractions with normal latency represent a group of patients with many features similar to DES.
Journal: Neurogastroenterology and motility
ISSN: 1350-1925
Volume: 28
Pages: 260 - 265
Publication year:2016
Keywords:A1 Journal article
BOF-keylabel:yes
BOF-publication weight:2
CSS-citation score:1
Authors:International
Authors from:Higher Education
Accessibility:Closed