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Disease severity in patients with visceral leishmaniasis is not altered by co-infection with intestinal parasites

Journal Contribution - Journal Article

Visceral leishmaniasis (VL) is a neglected tropical disease that affects the poorest communities and can cause substantial morbidity and mortality. Visceral leishmaniasis is characterized by the presence of Leishmania parasites in the spleen, liver and bone marrow, hepatosplenomegaly, pancytopenia, prolonged fever, systemic inflammation and low body mass index (BMI). The factors impacting on the severity of VL are poorly characterized. Here we performed a cross-sectional study to assess whether co-infection of VL patients with intestinal parasites influences disease severity, assessed with clinical and haematological data, inflammation, cytokine profiles and BMI. Data from VL patients was similar to VL patients co-infected with intestinal parasites, suggesting that co-infection of VL patients with intestinal parasites does not alter disease severity.
Journal: PLoS Neglected Tropical Diseases
ISSN: 1935-2727
Issue: 7
Volume: 11
Pages: 1 - 16
Number of pages: 16
Publication year:2017
Keywords:Paramedicine, Microbiology