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Development and characterization of BODIPY-derived tracers for fluorescent labeling of the endoplasmic reticulum

Journal Contribution - Journal Article

Visualization of the structure of the Endoplasmic Reticulum (ER) in living cells is important for the understanding of its function. Here we synthesized a library of 8-BODIPY labeled hydroxyquinoline derivatives and evaluated their spectroscopic properties, cytotoxicity, and intracellular localization. The compounds were easilyobtained in 34–80% yield. Based on the spectral properties and low cytotoxicity, we selected the quinolin-8-yl pentanoate derivative 17 for in vivo labeling of the ER.Fluorescence staining of the ER was evaluated by comparison with a commercial ER tracker. The molecules here developed are smaller than the alternatives commercially available while still presenting a high specificity towards the ER.
Journal: Dyes and Pigments
ISSN: 0143-7208
Volume: 176
Number of pages: 11
Publication year:2020
Keywords:Applied chemistry & chemical engineering, Materials science