Catheter Ablation versus Medical Therapy of Atrial Fibrillation in Patients with Heart Failure: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials

Subtitle:An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials

Background: Atrial fibrillation (AF) and heart failure (HF) often coexist and synergistically contribute to an increased risk of hospitalization, stroke, and mortality. Objective: To compare the efficacy of catheter ablation (CA) versus medical therapy (MT) in HF patients with AF. Methods: Electronic databases were queried for randomized controlled trials (RCTs) of CA versus MT of AF in patients with HF. Risk ratios (RRs), mean differences (MDs), and 95% confidence intervals (CIs) were measured using the Mantel–Haenszel method. Results: A total of nine RCTs enrolling 2155 patients met the inclusion criteria. Compared to MT, CA led to a significant reduction in the composite of all-cause mortality and HF hospitalization (24.6% vs. 37.1%; RR: 0.65 (95% CI: 0.53–0.80); p < 0.0001), all-cause mortality (8.8% vs. 13.6%; RR: 0.65 (95% CI: 0.51–0.82); p = 0.0005), HF hospitalization (15.4% vs. 22.4%; (RR: 0.67 (95% CI: 0.54–0.82); p = 0.0001), AF recurrence (31.8% vs. 77.0%; RR: 0.36 (95% CI: 0.24–0.54); p < 0.0001), and cardiovascular (CV) death (4.9% vs. 8.4%; RR: 0.58 (95% CI: 0.39–0.86); p = 0.007). CA improved the left ventricular ejection fraction (MD:4.76% (95% CI: 2.35–7.18); p = 0.0001), 6 min walk test (MD: 20.48 m (95% CI: 10.83–30.14); p < 0.0001), peak oxygen consumption (MD: 3.1 2mL/kg/min (95% CI: 1.01–5.22); p = 0.004), Minnesota Living with Heart Failure Questionnaire score (MD: −6.98 (95% CI: −12–03, −1.93); p = 0.007), and brain natriuretic peptide levels (MD:−133.94 pg/mL (95% CI: −197.33, −70.55); p < 0.0001). Conclusions: In HF patients, AF catheter ablation was superior to MT in reducing CV and all-cause mortality. Further significant benefits occurred within the ablation group in terms of HF hospitalizations, AF recurrences, the systolic function, exercise capacity, and quality of life.

Publication year:2022

Keywords:atrial fibrillation, catheter ablation, heart failure, medical therapy, randomized controlled trials, recurrence, amiodarone, antiarrhythmic agent, brain natriuretic peptide, adult, adverse event, aged, all cause mortality, article, cardiorespiratory fitness, cardiovascular mortality, cause of death, clinical outcome, congestive heart failure, disease severity, embolism, esophagus disease, exercise, female, follow up, heart left ventricle ejection fraction, heart tamponade, hospitalization, human, liver toxicity, lung toxicity, male, meta analysis, middle aged, Minnesota Living with Heart Failure Questionnaire, multicenter study (topic), New York Heart Association class, paroxysmal atrial fibrillation, peak oxygen uptake, pericardial effusion, persistent atrial fibrillation, pulmonary vascular disease, quality of life, randomized controlled trial (topic), recurrent disease, six minute walk test, stenosis, systematic review, thyroid disease, General & internal medicine

Accessibility:Open