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Publication

ADAR1 edits the SenZ and SenZ-ability of RNA

Journal Contribution - Journal Editorial

Some RNAs can assume a Z conformation, an unusual, left-handed turn. In this issue of Immunity, three studies report that mutations in the Za-RNA binding domain of the adenosine deaminase ADAR1 are sufficient to induce autoinflammatory disease in mice, which models human Aicardi-Goutie` res syndrome, highlighting the important role of Z-RNA editing in limiting innate immune recognition of endogenous RNA.

Journal: Immunity
ISSN: 1074-7613
Issue: 9
Volume: 54
Pages: 1909-1911
Publication year:2021
Keywords:MUTATIONS, DOMAIN, DSRNA
Accessibility:Closed