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Project

In vitro generation of AML specific T cells from gematopoietic stem cells and functional characterization of these cells in an in vivo animal model

Hematopoietic stem cells will be transduced to express a T Cell Receptor. This receptor will be optained by immunizing against WT1 tumor antigen. The T cell receptor genes will be cloned from WT1 speciific T cells and subsequently used for transduction of the stem cells. Stem cells will be differentiated in vitro to T cells and functionality will be assayed in an in vivo animal model.

Date:1 Jan 2010 →  31 Dec 2015
Keywords:cell therapy, T cells, stem cells
Disciplines:Immunology, Laboratory medicine, Hematology, Systems biology