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Project
Unveiling the role of nuclear compartmentalisation in laminopathies with intelligent high content imaging and spatial proteomics.
Laminopathies are orphan diseases caused by mutations in the LMNA gene, which encodes A-type lamins. Recent evidence suggests that lamin defects cause abnormal nucleocytoplasmic compartmentalization. This feature is prone to contribute significantly to disease development in laminopathies, and may also play an important role in aging and certain cancers. With an eye on its medical potential, we want to expose the exact underpinnings of defective compartmentalization.
Date:1 Oct 2014 → 30 Sep 2018
Keywords:NUCLEUS, LAMINOPATHIES, CELL BIOLOGY, MICROSCOPICAL TECHNIQUES
Disciplines:Multimedia processing, Biological system engineering, Signal processing, Morphological sciences, Oncology