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Project

Unravelling the systemic effects of primary surgery and perioperative use of anti-inflammatory drugs in primary breast cancer patients according to adiposity.

Breast cancer (BC) is the most frequent cancer in women. Obesity and inflammation (including surgery-related) are conditions favouring BC relapse. We have previously reported that perioperative administration of the non-steroidal anti-inflammatory drug (NSAID) ketorolac reduces the risk of early BC relapses. This effect is particularly pronounced in obese patients. It has been hypothesized that surgery causes a transient systemic inflammation favouring the outgrowth of disseminated cancer cells and that NSAID treatment blunts this effect. However, there is paucity of clinical and experimental data supporting this hypothesis. In this context, we want to specifically address the following questions: 1. Does primary surgery cause systemic inflammation and is this modulated by the presence of the tumour? 2. Is the systemic inflammatory response different according to patient adiposity? 3. What is the effect of perioperative administration of NSAIDs on the systemic response and disease progression?

Date:1 Oct 2019 →  1 Oct 2023
Keywords:Postoperative breast cancer relapse
Disciplines:Cancer biology
Project type:PhD project