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Project

Unraveling the structural/topological aspects and the energetics related to complex DNA or chromatin interactions of high order nucleoprotein complexes involved in HIV/AIDS and/or leukemia.

The aim of the project is to develop and combine different single-molecule techniques in a parallel fashion as well as in integrated setups, together with in silico approaches and tools from molecular biology and virology, to dissect the molecular interactions that determine the structure and energetics of higher-order nucleoprotein assemblies in vitro and in vivo. The project addresses several questions in contemporary biomedical research related to the development and treatment of the acquired immune deficiency syndrome (AIDS) and leukemia, and the design of safer vectors for gene therapy.
Date:1 Oct 2013 →  30 Sep 2017
Keywords:HIV/AIDS, Chromatin interactions
Disciplines:Linguistics