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Unraveling of protective innate and adaptive immune responses to SARS-CoV-2 in the setting of HCoV crossreactivity

A thorough understanding of the immune response against SARS-CoV-2 is crucial for effective epidemiological, immunotherapeutic and immunoprophylactic COVID-19 management. In this project, we first focus on a comprehensive mapping of epitope and neutralizing antibody profiles with different COVID-19 disease severity. Since antibodies may also have a cross-reactive origin resulting from previous HCoV infections, this study will include complete cross-reactivity mapping. The multi-epitope reactivity patterns will be correlated with disease and exposure severity. In the next step, we will perform a further biological profiling of interesting patterns related to disease severity and/or in vitro protective features by including in-depth immunological characterization of the B and T cell responses, antibody CDR (complementarity-determining region) profiling, B cell receptor sequencing and T cell response profiling and T cell receptor sequencing. This outcome is critical for development of reliable serology and seroprevalence tests, for vaccine selection and evaluation, and for our understanding of the immunopathogenesis of SARS-CoV-2 infection.
Date:1 Jan 2021 →  Today
Keywords:SARS-CoV-2, COVID-19, immunovirological profiling
Disciplines:Adaptive immunology