Understanding the transcriptome dynamics of migratory mechanisms of dendritic cells and regulatory T-cells in MS using RNA-Seq. (R-7758)

Control of lymphocyte entry and migration within the brain is vital to regulate protective and pathological responses. But what prompts cells to enter the brain? In the current proposal, we aim to delineate genetic, phenotypic and functional differences between migrating and non-migrating key immune-regulatory cells, using an in vitro blood-brain barrier. In doing so, we intend to throw light on the underlying pathological mechanisms and to devise better treatment for disease by identifying interesting targets for therapeutic intervention. Indeed, increased understanding of the mechanisms of leukocyte trafficking into the brain might provide insights to augment protective immune responses to infection and cancer while minimizing collateral damage. On the other hand, ameliorating or modulating pathologic responses while still allowing normal immune surveillance is the ultimate therapeutic goal in neuro-inflammatory diseases, such as multiple sclerosis.

Keywords:Dendritic cells, MULTIPLE SCLEROSIS, T-cells

Disciplines:Immunology, Laboratory medicine, Medical systems biology, Molecular and cell biology

Project type:Collaboration project