Towards a mechanism-based in silico model to predict lipid digestion as influenced by food product design
This postdoc project will aim to build a mechanism-based multiresponse model to describe the time dependent evolution of multiple lipid digestion products as a function of digestion time. In order to test the robustness of this model, the mechanisms put forward need to be validated for different lipid digestion data sets. This multiresponse modelling will give us quantitative confirmation about the valid reaction mechanism as well as information about the rate limiting step in the lipolysis reaction (i.e. primary modelling). The second objective of the current project is to update the proposed digestion procedure of Minekus et al. (2014) and use it to evaluate the effect of different (micro)structural characteristics of emulsified lipids on the lipolysis reaction kinetics. Eventually, these data can be used as input for secondary modelling as well, which would describe the effect of emulsion structural characteristics on lipolysis kinetic parameters.