Targeting arterial stiffening to prevent incident hypertension and associated organ damage.

Little is known about the mechanisms that cause arterial stiffening with aging. Structural components are known to alter arterial stiffness. Although the details are unknown, active components of the arterial wall have been shown to play a role also. Here, we want to investigate whether and how active components determine arterial stiffness. Understanding these mechanisms is crucial if we aim to improve health care management in patients with elevated arterial BP and arterial stiffness.

Keywords:CARDIOVASCULAR DISEASE, ARTERIAL STIFFENING, PHARMACOLOGY, PATHOPHYSIOLOGY

Disciplines:Cardiac and vascular medicine

Project type:Collaboration project