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Project

Synthesis, decoration and biological evaluation of novel fused 7-deazapurine skeletons.

Purine analogs, including the 7-deazapurines (pyrrolo[2,3-d]pyrimidinen) are, due to their structural analogy with ATP, interesting substrates to achieve inhibition of ATP-binding proteins. In the framework of this project new annulated 7-deazapurine targets will be synthesized. The synthesis of these annulated 7-deazapurine target molecules is based on four transition metal catalyzed direct C-H activations.
Date:1 Jan 2014 →  31 Dec 2017
Keywords:ORGANIC SYNTHESIS
Disciplines:Organic chemistry