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Project

Supramolecular structure-function relationships of antimicrobial peptides from the viscosin group: a combined approach via synthesis and advanced NMR structure analysis

Antimicrobial peptides or AMPs are a potential source of new first line defense antibiotics, which often act through the formation of supramolecular assemblies inside the cell membrane, e.g. by pore formation.

In this mutlidisciplinary project a generic synthesis approach will be developed, allowing the production of analogues featuring a number of modifications in composition and stereochemistry. Using recently developed NMR approaches the self-assembly and supramolecular structure will be studied and correlated to the primary sequence, as well as biological activity.

Date:1 Oct 2011 →  30 Sep 2015
Keywords:synthesis, structure analysis, antibiotics
Disciplines:Organic chemistry, Analytical chemistry