Study of the role of NF-kB regulatory signalling molecules involved in multiple sclerosis through gene targeting in the mouse

In this project we investigate the role of NF-kB in multiple sclerosis. Therefore we make use of knockout mice that are deficient in specific NF-kB regulatory genes, and we use these mice in models of multiple sclerose. In this way we hope to better understand the function of specific genes in multiple sclerosis.