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Study of the pain-producing and pain-potentiating effects of prolonged exposure to Endothelin-1 (ET-1).
Endothelin-1 is being increasingly recognized as an important molecule in the development and progression of cancer, but also in the occurrence of cancer pain. So far, all studies have used acute administration of ET-1, bearing little resemblance with the prolonged exposure observed in clinical conditions. It is therefore proposed to investigate the effects of chronic exposure to ET-1 on signs of spontaneous and evoked pain behaviour.
Date:1 Jan 2022 → Today
Keywords:ENDOTHELIN-1, CANCER, NEUROPATHIC PAIN
Disciplines:Pain medicine anaesthesiology