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Study of the pain-producing and pain-potentiating effects of prolonged exposure to Endothelin-1 (ET-1).
Endothelin-1 is being increasingly recognized as an important molecule in the development and progression of cancer, but also in the occurrence of cancer pain. So far, all studies have used acute administration of ET-1, bearing little resemblance with the prolonged exposure observed in clinical conditions. It is therefore proposed to investigate the effects of chronic exposure to ET-1 on signs of spontaneous and evoked pain behaviour.
Date:1 Feb 2009 → 31 Dec 2010
Keywords:ENDOTHELIN-1, CANCER, NEUROPATHIC PAIN
Disciplines:Anaesthesiology, Intensive care and emergency medicine, Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing