Study on the effect of phytate (inositol hexakisphosphate) on the development of vascular calcification in rats with chronic renal failure

Vascular calcification is the major risk factor for the high cardiovascular mortality in patients with end-stage renal disease. Current therapies, mainly focusing on disturbances in mineral metabolism such as hyperphosphatemia and secondary hyperparathyroidism, reduce the progression of vascular calcification, but these agents can not completely block the calcification process and suffer from a poor compliance. A new therapeutic approach consists of direct interference with the formation of the calcified lesions. Therefore, the current project aims to investigate the effect of phytic acid, which prevents the formation and growth of calcium-phosphate microcrystals in soft tissue, on the development of vascular calcification in rats with chronic renal failure.

Keywords:THERAPEUTICS, VASCULAR CALCIFICATION, CHRONIC RENAL FAILURE

Disciplines:Cardiac and vascular medicine, Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences